中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2019, Vol. 41 ›› Issue (1): 63-67.doi: 10.3881/j.issn.1000-503X.10517

• 论著 • 上一篇    下一篇

α-平滑肌肌动蛋白表达在进展期结直肠癌化疗疗效预测及预后中的意义

谷俊杰,孙昭,赵林,白春梅()   

  1. 中国医学科学院 北京协和医学院 北京协和医院肿瘤内科,北京 100730
  • 收稿日期:2018-05-03 出版日期:2019-02-28 发布日期:2019-03-06
  • 通讯作者: 白春梅 E-mail:baichunmei1964@163.com
  • 基金资助:
    中国医学科学院医学与健康科技创新工程(2017-I2M-4-003)

Expression of α-smooth Muscle Actin in Advanced Colorectal Cancer Tissue and Its Significance in Chemotherapy Response Prediction and Prognosis

GU Junjie,SUN Zhao,ZHAO Lin,BAI Chunmei()   

  1. Department of Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2018-05-03 Online:2019-02-28 Published:2019-03-06
  • Contact: Chunmei BAI E-mail:baichunmei1964@163.com
  • Supported by:
    Supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2017-I2M-4-003)

摘要:

目的 探讨α-平滑肌肌动蛋白(α-SMA)表达与进展期结直肠癌化疗疗效及预后的相关性。方法 采用免疫组织化学方法,检测52例接受奥沙利铂联合氟尿嘧啶化疗的进展期结直肠癌患者标本中α-SMA的表达,分析其与临床病理因素和化疗疗效的相关性,并进行生存分析。结果 52例患者中,29例(55.8%)为α-SMA高表达,α-SMA蛋白的表达与患者的年龄(χ 2=0.113,P=0.730)、性别(χ 2=0.515,P=0.332)、肿瘤部位(χ 2=3.675,P=0.159)、组织分化程度(χ 2=1.852,P=0.604)均无显著相关性。α-SMA高表达者化疗耐药率为65.5%(19/29),显著高于α-SMA低表达者的13.0%(3/23)(χ 2=14.470,P=0.000)。α-SMA高表达者的无进展生存期显著短于α-SMA低表达者[(6.4±1.0)个月比(16.0±3.5)个月; χ log ? rank 2 =5.985,P=0.018]。 结论 α-SMA高表达与进展期结直肠癌患者对奥沙利铂联合氟尿嘧啶类药物耐药相关。

关键词: α-平滑肌肌动蛋白表达;, 结直肠癌, 疗效, 预后

Abstract:

Objective To investigate the expression of α-smooth muscle actin(α-SMA)in advanced colorectal cancer tissue and its association with chemotherapy response and prognosis.Methods The expression of α-SMA was detected by immunohistochemistry in tissues from 52 advanced colorectal cancer patients who received oxaliplatin plus 5-fluorouracil regimen as first-line chemotherapy. Its relationship with clinical characteristics,chemotherapy response,and survival were analyzed.Results Of these 52 patients,29(55.8%)were α-SMA overexpression,and the expression of α-SMA protein was not significantly associated with the age(χ 2=0.113,P=0.730),gender(χ 2=0.515,P=0.332),tumor location(χ 2=3.675,P=0.159),and tissue differentiation(χ 2=1.852,P=0.604). The chemotherapy resistance rate was 65.5%(19/29)in patients with high α-SMA expression,which was significantly higher than that (13.0%,3/23)in patients with low α-SMA expression(χ 2=14.470,P=0.000). Patients with high α-SMA expression exhibited a significantly shorter progression-free survival(PFS)compared with those with low α-SMA expression [(6.4±1.0)months vs.(16.0±3.5)months; χ log - rank 2 =5.985,P=0.018]. Conclusion High α-SMA expression is associated with resistance to first-line chemotherapy and poor prognosis in advanced colorectal cancer patients.

Key words: α-smooth muscle actin expression;, colorectal cancer, chemotherapy response, prognosis

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