中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2019, Vol. 41 ›› Issue (3): 408-414.doi: 10.3881/j.issn.1000-503X.10774

• 综述 • 上一篇    下一篇

卵泡发生过程中能量代谢需求及调控机制的研究进展

屠豪炎1,雷小灿2,霍鹏3,乐江华4,张顺1()   

  1. 1 桂林医学院附属医院生殖医学中心,广西桂林 541001
    2 遵义医学院基础医学院,贵州遵义 563100
    3 公共卫生学院,广西桂林 桂林医学院 541001
    4 附属医院产科,广西桂林 桂林医学院 541001
  • 收稿日期:2018-08-16 出版日期:2019-06-30 发布日期:2019-07-04
  • 通讯作者: 张顺 E-mail:huageshunzi@163.com
  • 基金资助:
    国家自然科学基金(31460282);国家自然科学基金(81860733)

Energy Demand and Its Regulatory Mechanism during Folliculogenesis

TU Haoyan1,LEI Xiaocan2,HUO Peng3,LE Jianghua4,ZHANG Shun1()   

  1. 1 Department of Reproductive Medicine Center,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi 541001,China
    2 School of Basic Medicine,Zunyi Medical University,Zunyi,Guizhou 563100,China
    3 School of Public Health, Affiliated Hospital,Guilin Medical University,Guilin,Guangxi 541001,China
    4 Department of Obestetrical,Affiliated Hospital,Guilin Medical University,Guilin,Guangxi 541001,China
  • Received:2018-08-16 Online:2019-06-30 Published:2019-07-04
  • Contact: Shun ZHANG E-mail:huageshunzi@163.com
  • Supported by:
    Supported by the National Nature Sciences Foundation of China(31460282);Supported by the National Nature Sciences Foundation of China(81860733)

摘要:

卵泡的生长和发育均受到来自颗粒细胞、卵泡膜细胞和卵母细胞自分泌或者旁分泌的基因、激素以及生长因子的作用和调控。其中,颗粒细胞糖酵解过程所产生的丙酮酸、乳酸等代谢产物是卵泡发生最主要的能量来源之一,在卵泡发生和卵母细胞成熟过程中发挥重要作用。开展卵泡颗粒细胞糖酵解代谢产物及限速酶变化的研究有助于更好地阐明卵泡发生过程中能量需求的分子机制,为临床女性因卵泡发育异常导致的不孕症提供积极的治疗手段奠定基础。本文总结了不同状态下卵泡发生过程中的能量需求及调控机制。

关键词: 卵泡发生, 颗粒细胞, 糖酵解, 调控机制

Abstract:

The growth and development of follicles are regulated by genes,hormones and growth factors autocrined and paracrined from granulosa cells,theca cells,and oocytes.Products of glycolysis from granulosa cells such as pyruvate and lactate are one of the main energy sources,which play an important role during folliculogenesis and follicle maturity.Studies on the changes of the products and rate-limiting enzymes during granulosa cells’ glycolysis help to clarify the molecular mechanism of energy demand in folliculogenesis and guide the clinical treatment of infertility due to abnormal follicular development.This article reviews recent research advances in the energy demand and regulatory mechanism in different states of folliculogenesis.

Key words: folliculogenesis, granulosa cells, glycolysis, regulatory mechanism

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