中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2019, Vol. 41 ›› Issue (3): 425-429.doi: 10.3881/j.issn.1000-503X.11029

• 综述 • 上一篇    下一篇

Wnt信号通路在视网膜干细胞修复中的作用

杨琨,王雁()   

  1. 天津市眼科医院 天津医科大学眼科临床学院 天津市眼科研究所 天津市眼科学与视觉科学重点实验室,天津 300020
  • 收稿日期:2018-11-20 出版日期:2019-06-30 发布日期:2019-07-04
  • 通讯作者: 王雁 E-mail:wangyan7143@vip.sina.com

Role of Wnt Signaling Pathway in Stem Cells Derived Retinal Regeneration

YANG Kun,WANG Yan()   

  1. Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin Eye Institute,Clinical College of Ophthalmology of Tianjin Medical University,Tianjin Eye Hospital,Tianjin 300020,China
  • Received:2018-11-20 Online:2019-06-30 Published:2019-07-04
  • Contact: Yan WANG E-mail:wangyan7143@vip.sina.com

摘要:

人类视网膜的损伤和相关的神经退行性病变通常伴随着不可逆的视力丧失,干细胞疗法一直被认为是该类疾病有效的治疗方式。近年研究发现,哺乳动物甚至人类的眼中尚存在着沉寂的视网膜干细胞,在一定条件下,这些细胞可以被激活从而修复损伤的视网膜。Wnt信号通路是传递生长刺激信号的重要通路,调控着细胞的增殖、分化和凋亡,尤其在调控干细胞分化过程中起着重要作用。本文主要对Wnt信号通路在视网膜干细胞修复方面的调控作用以及视网膜干细胞的来源做一综述。

关键词: Wnt, 信号通路, 干细胞, 视网膜再生

Abstract:

Human optic nerve injury and its associated neurodegenerative diseases are often followed by permanent vision loss.Stem cell therapy has long been considered a promising mode to treat retinal degenerative diseases.Recent studies revealed that there are silent retinal stem cells in the eyes of mammals and even humans.These stem cells can be activated again under certain conditions and differentiate into retinal neurons to repair the damaged retina.Wnt signaling pathway plays a crucial role in conducting growth-stimulating signals and regulates cell proliferation,differentiation and apoptosis.This article review the regulatory effect of Wnt signaling pathway on stem cells-based retinal regeneration and the sources of retinal stem cells.

Key words: Wnt, signaling pathway, stem cells, retinal regeneration

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