中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2020, Vol. 42 ›› Issue (6): 810-814.doi: 10.3881/j.issn.1000-503X.11427

• 综述 • 上一篇    下一篇

翻译后修饰与子宫内膜异位症研究进展

朱靓雯,薛晴()   

  1. 北京大学第一医院妇产科,北京 100034
  • 收稿日期:2019-04-10 出版日期:2020-12-30 发布日期:2021-01-11
  • 通讯作者: 薛晴 E-mail:xueqingqq@hotmail.com
  • 基金资助:
    国家科技部重点专项(2017YFC1001203);国家科技部重点专项(2017YFC1001203)

Advances in Post-translational Modifications and Endometriosis

ZHU Jingwen,XUE Qing()   

  1. Department of Gynecology and Obstetrics,Peking University First Hospital,Beijing 100034,China
  • Received:2019-04-10 Online:2020-12-30 Published:2021-01-11
  • Contact: XUE Qing E-mail:xueqingqq@hotmail.com
  • Supported by:
    National Key R&D Program of China(2017YFC1001203);National Key R&D Program of China(2017YFC1001203)

摘要:

蛋白质是生命活动的承担者,需要经过不同程度的翻译后修饰才能发挥其功能。常见的蛋白质翻译后修饰过程有磷酸化、乙酰化、泛素化、糖基化和甲基化等,这些修饰可以改变蛋白质的功能,在多种疾病中发挥重要作用。子宫内膜异位症是育龄期妇女的常见疾病,其具体发病机制目前尚不清楚。近年研究表明,蛋白质翻译后修饰可能参与子宫内膜异位症发生发展。本文对蛋白质翻译后修饰在子宫内膜异位症发病机制、药物治疗等方面的研究进行综述,为子宫内膜异位症治疗及研究方向提供新思路。

关键词: 子宫内膜异位症, 翻译后修饰, 发病机制

Abstract:

Proteins exert their roles in life activities via post-translational modifications(PTMs),which include phosphorylation,acetylation,ubiquitination,glycosylation,and methylation.These modifications can change the functions of proteins and play key roles in a variety of diseases.Endometriosis is a common disease in women of childbearing age,although its molecular mechanisms remain unclear.Recent studies have shown that PTMs may be involved in the pathogenesis of endometriosis.Here we review the roles of PTMs in the occurrence and development of endometriosis and the potential medical treatments.

Key words: endometriosis, post-translational modifications, pathogenesis

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