中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2020, Vol. 42 ›› Issue (4): 559-561.doi: 10.3881/j.issn.1000-503X.11470

• 综述 • 上一篇    下一篇

寻常痤疮发病机制相关信号通路的研究进展

汤红燕1,肖斌1,刘鑫1,杨桂兰2()   

  1. 1兰州大学第二医院皮肤科,兰州 730000
    2南方医科大学深圳医院皮肤科,广东深圳 518000
  • 收稿日期:2019-04-22 出版日期:2020-08-30 发布日期:2020-09-08
  • 通讯作者: 杨桂兰 E-mail:drgly2006@126.com
  • 基金资助:
    皮肤病学教育部重点实验室(HS2017-1-003)

Signaling Pathways in the Pathogenesis of Acne Vulgaris

TANG Hongyan1,XIAO Bin1,LIU Xin1,YANG Guilan2()   

  1. 1Department of Dermatology,the Second Affiliated Hospital of Lanzhou University,Lanzhou 730000,China
    2Department of Dermatology,Shenzhen Hospital of Southern Medical University,Shenzhen,Guangdong 518000,China
  • Received:2019-04-22 Online:2020-08-30 Published:2020-09-08
  • Contact: YANG Guilan E-mail:drgly2006@126.com
  • Supported by:
    Key Laboratory of Dermatology Ministry of Education(Fudan University Institute of Dermatology)(HS2017-1-003)

摘要:

寻常痤疮是一种毛囊皮脂腺单位的炎症疾病,在青少年中的发病率高达85%,发病机制与雄激素、皮脂分泌、嗜脂性微生物感染、免疫-炎症反应等密切相关。本文从炎症信号通路、皮脂分泌通路方面,综述与痤疮相关的信号转导通路。

关键词: 寻常痤疮, 发病机制, 信号转导通路

Abstract:

Acne vulgaris is an inflammatory disease of hair follicle sebaceous gland units,with an incidence of up to 85% in adolescents.The pathogenesis is closely related to androgen,sebum secretion,lipophilic microbial infection,and immune-inflammatory reaction.This article reviews the signaling pathways related to acne from the aspects of inflammatory signaling pathways and sebum secretion pathways.

Key words: acne vulgaris, pathogenesis, signaling pathways

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