中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2020, Vol. 42 ›› Issue (6): 815-819.doi: 10.3881/j.issn.1000-503X.11482

• 综述 • 上一篇    下一篇

L-精氨酸与α1-肾上腺素能受体在肾功能调节中的作用

张红,张正红,张陈珊,王正朝()   

  1. 福建师范大学生命科学学院 福建省发育与神经生物学重点实验室,福州 350007
  • 收稿日期:2019-04-24 出版日期:2020-12-30 发布日期:2021-01-11
  • 通讯作者: 王正朝 E-mail:zcwang@fjnu.edu.cn
  • 基金资助:
    福建省自然科学基金(2017J01626);福建省自然科学基金(2018J01722);福建省自然科学基金(2020J01176);福建省教育厅科技项目(JZ160426);国家级大学生创新训练计划项目(201910394023);福建师范大学教改项目(Y201809);福建师范大学教改项目(P201801016);福建师范大学教改项目(FZSKG2018002);福建师范大学大学生创新训练计划项目(CXXL2020291);福建师范大学大学生创新训练计划项目(CXXL2020293)

Effects of L-Arginine and α1-Adrenergic Receptor on the Regulation of Renal Functions

ZHANG Hong,ZHANG Zhenghong,ZHANG Chenshan,WANG Zhengchao()   

  1. Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences, Fujian Normal University,Fuzhou 350007,China
  • Received:2019-04-24 Online:2020-12-30 Published:2021-01-11
  • Contact: WANG Zhengchao E-mail:zcwang@fjnu.edu.cn
  • Supported by:
    Fujian Provincial Natural Science Foundation(2017J01626);Fujian Provincial Natural Science Foundation(2018J01722);Fujian Provincial Natural Science Foundation(2020J01176);Fujian Provincial Science and Technology Project of the Education Department(JZ160426);National Training Program of Innovation and Enterpreneurship for Undergraduates(201910394023);Educational Reform Project of Fujian Normal University(Y201809);Educational Reform Project of Fujian Normal University(P201801016);Educational Reform Project of Fujian Normal University(FZSKG2018002);Training Program of Innovation and Enterpreneurship for Undergraduates of Fujian Normal University(CXXL2020291);Training Program of Innovation and Enterpreneurship for Undergraduates of Fujian Normal University(CXXL2020293)

摘要:

肾脏是机体重要的脏器之一,具有排泄和部分内分泌功能,对体内正常生理状态的维持至关重要。L-精氨酸是体内合成一氧化氮(NO)等分子的前体,可以通过血管活性因子NO参与细胞内和细胞间的信号传递,对维持肾脏正常生理功能十分重要。α1-肾上腺素能受体(α1-AR)介导交感神经对机体心脏、血管、神经系统等进行调节,血管平滑肌中分布的α1-AR主要介导血管收缩。研究显示肾衰竭、糖尿病、高血压和左心室肥大等疾病状态的大鼠α1-AR对激动剂的反应性降低,反应性的变化影响肾血管舒缩、肾血流动力学状态与肾血管张力等,从而参与肾功能的调节。本文通过阐述NO与α1-AR的作用方式及其对肾功能调节的影响,进而分析L-精氨酸提高α1-AR对激动剂反应性的途径,为临床提供参考资料。

关键词: L-精氨酸, 一氧化氮, α1-肾上腺素能受体, 肾脏

Abstract:

Kidney is one of the important organs of the body.With both excretory and endocrine functions,it plays a vital role in regulating the normal physiological state.As a precursor of the nitric oxide(NO)synthesis in vivo,L-arginine is involved in intracellular and intercellular signaling via NO,a vasoactive factor,thus plays a key role in maintaining the normal physiological functions of the kidney.Alpha1-adrenergic receptor(α1-AR)mediates sympathetic nerves to regulate the heart,blood vessels,and nervous system of the body.The α1-AR distributed in vascular smooth muscle mainly mediates vasoconstriction.The responsiveness of α1-AR to adrenergic agonists decreases in rat models of kidney failure,diabetes,hypertension,and left ventricular hypertrophy,which affects the hemodynamic state and vascular tone of the kidney.Here we analyze the ways via which L-arginine improves the responsiveness of α1-AR to its agonists by ellucidating the action mode of NO/α1-AR and their effects on renal functions.

Key words: L-arginine, nitric oxide, α1-adrenergic receptor, kidney

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