中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2021, Vol. 43 ›› Issue (3): 452-461.doi: 10.3881/j.issn.1000-503X.12654

• 综述 • 上一篇    下一篇

继发性肺结核致病机制的再认识及索状因子在其中的作用

刘镇铭,艾沁悦,耿雪薇,黄胜,王嘉军,石廷玉()   

  1. 湖北民族大学医学部基础医学院病原生物学教研室,湖北恩施 445000
  • 收稿日期:2020-02-27 出版日期:2021-06-30 发布日期:2021-07-09
  • 通讯作者: 石廷玉 E-mail:shitingyu198@126.com
  • 基金资助:
    国家自然科学基金青年基金(81801979);国家自然科学基金青年基金(31600073);湖北省自然科学基金青年项目(2018CFB384);湖北民族大学大学生创新创业训练计划项目(201910517004);湖北民族大学大学生创新创业训练计划项目(2010517005)

Pathogenesis of Secondary Pulmonary Tuberculosis and Role of Cord Factor in Secondary Infection

LIU Zhenming,AI Qinyue,GENG Xuewei,HUANG Sheng,WANG Jiajun,SHI Tingyu()   

  1. Department of Pathogenic Biology,Basic Medical College,Medical School, Hubei Minzu University,Enshi,Hubei 445000,China
  • Received:2020-02-27 Published:2021-06-30 Online:2021-07-09
  • Contact: SHI Tingyu E-mail:shitingyu198@126.com
  • Supported by:
    National Natural Sciences Foundation of China Youth Fund(81801979);National Natural Sciences Foundation of China Youth Fund(31600073);Youth Project of Hubei Natural Science Foundation(2018CFB384);Hubei University Students Innovation and Entrepreneurship Training Plan(201910517004);Hubei University Students Innovation and Entrepreneurship Training Plan(2010517005)

摘要:

原发性结核与继发性结核是两个完全不同的致病过程,目前对原发性结核的致病机制有了较清楚认识,而对继发性结核致病机制的认识并不完全清楚。本文总结了广泛接受的继发感染致病机制存在的问题及产生的原因,以及致病机制新的认识和索状因子在其中的作用,希望促进对结核分枝杆菌继发感染致病机制的理解,为疫苗研发和药物开发提供新的认识。

关键词: 结核分枝杆菌, 原发感染, 继发性感染, 索状因子, 肺结核

Abstract:

The primary and secondary tuberculosis features two completely different pathogenesis.At present,the pathogenesis of primary tuberculosis has been clear,whereas that of secondary tuberculosis remains unclear.In order to decipher the mechanism of secondary infection of Mycobacterium tuberculosis and provide insights into vaccine research and drug development,this paper reviews the problems of the widely accepted mechanism of secondary infection,the new findings of the research on the mechanism,as well as the role of cord factors.

Key words: Mycobacterium tuberculosis, primary infection, secondary infection, cord factor, pulmonary tuberculosis

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