中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2021, Vol. 43 ›› Issue (4): 628-633.doi: 10.3881/j.issn.1000-503X.13146

• 综述 • 上一篇    下一篇

CD4+T细胞介导调控神经炎症在神经退行性疾病中的研究进展

陈雯奕,钱玥,陈天云,顾小萍()   

  1. 南京大学医学院附属鼓楼医院麻醉科,南京 210008
  • 收稿日期:2020-07-07 出版日期:2021-08-30 发布日期:2021-09-03
  • 通讯作者: 顾小萍 E-mail:xiaopinggu@nju.edu.cn
  • 基金资助:
    国家自然科学基金(81730033);十三五科教强卫工程—江苏省重点人才项目(ZDRCA2016069)

Research Progress of CD4+T Cells-mediated Regulation of Neuroinflammation Involved in Neurodegenerative Diseases

CHEN Wenyi,QIAN Yue,CHEN Tianyun,GU Xiaoping()   

  1. Department of Anesthesiology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China
  • Received:2020-07-07 Published:2021-08-30 Online:2021-09-03
  • Contact: GU Xiaoping E-mail:xiaopinggu@nju.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81730033);Program of Strengthening Health Through Science and Education During the 13th Five-Year Plan Period-Key Talents Program of Jiangsu Province(ZDRCA2016069)

摘要:

神经退行性疾病是一类与神经炎症、氧化应激、衰老等多种因素有关的疾病,可导致认知及运动功能障碍。近年多项研究提示神经退行性疾病的发生发展与适应性免疫反应有关,CD4+T细胞作为适应性免疫细胞参与其中。CD4+T细胞可根据不同的途径分化成不同的功能亚群,包括辅助性T细胞亚群及调节性T细胞亚群等,不同亚群可对阿尔茨海默病、帕金森病、多发性硬化症和肌萎缩性侧索硬化症等神经退行性疾病进展产生不同的调节作用。本文主要综述CD4+T细胞在神经退行性疾病发病过程中的作用及研究进展。

关键词: CD4+T细胞, 神经退行性疾病, 适应性免疫

Abstract:

Neurodegenerative diseases are associated with neuroinflammation,oxidative stress,and aging,which can lead to cognitive and motor dysfunctions.Recent studies suggest that the development of neurodegenerative diseases is related to adaptive immunity,in which CD4+T cells are involved as adaptive immune cells.Through different pathways,CD4+T cells differentiate into effector and regulatory subsets,which may have different effects on the progression of neurodegenerative diseases such as Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,and amyotrophic lateral sclerosis.Here,we review the role and research progress of CD4+T cells in neurodegenerative diseases.

Key words: CD4+T cell, neurodegenerative disease, adaptive immunity

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