中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2021, Vol. 43 ›› Issue (2): 253-258.doi: 10.3881/j.issn.1000-503X.13177

• 综述 • 上一篇    下一篇

维生素D补充与妊娠期糖尿病患者血糖控制和不良母婴结局的研究进展

王朦朦1,王颖1,陈赵静1,徐畅青1,王乙1,杨军1,2,张龙1,李红娟1()   

  1. 1杭州师范大学医学部公共卫生学院,杭州 311121
    2浙江大学医学院附属妇产科医院浙江省子宫恶性肿瘤诊治技术研究中心,杭州 310006
  • 收稿日期:2020-07-16 出版日期:2021-04-28 发布日期:2021-05-10
  • 通讯作者: 李红娟 E-mail:lihj@hznu.edu.cn
  • 基金资助:
    国家自然科学基金(31971138);浙江省自然科学基金(LZ19H260001)

Research Progress of the Effects of Vitamin D Supplementation on Glycemic Control and Adverse Maternal-neonatal Outcomes in Gestational Diabetes Mellitus Patients

WANG Mengmeng1,WANG Ying1,CHEN Zhaojing1,XU Changqing1,WANG Yi1,YANG Jun1,2,ZHANG Long1,LI Hongjuan1()   

  1. 1School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China
    2Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China
  • Received:2020-07-16 Online:2021-04-28 Published:2021-05-10
  • Contact: LI Hongjuan E-mail:lihj@hznu.edu.cn
  • Supported by:
    National Natural Sciences Foundation of China(31971138);Zhejiang Provincial Natural Sciences Foundation(LZ19H260001)

摘要:

妊娠期糖尿病(GDM)可导致孕妇血糖紊乱以及各种不良母婴结局的发生。维生素D可改善葡萄糖耐量和胰岛素敏感性,在孕期服用维生素D理论上可改善GDM所致的孕妇血糖紊乱及不良母婴结局。现有研究证实维生素D缺乏与GDM不良母婴结局有关,但有关维生素D补充对GDM患者血糖控制及母婴结局影响的研究尚无统一结论。本文综述近年有关维生素D补充与GDM患者血糖控制以及不良母婴结局的研究进展,以期为提高GDM患者分娩质量及改善母婴结局提供指导作用。

关键词: 维生素D, 妊娠期糖尿病, 维生素D补充, 不良母婴结局

Abstract:

Gestational diabetes mellitus(GDM)can cause blood glucose disorders in pregnant women and result in adverse maternal-neonatal outcomes.Vitamin D(VD)can improve glucose tolerance and insulin sensitivity,and thus theoretically,VD supplementation during pregnancy could improve glycemic control as well as maternal-neonatal outcomes in GDM patients.Although studies have shown that VD deficiency is associated with poor maternal-neonatal outcomes in GDM patients,no solid conclusion has been drawn with regard to the effects of VD supplementation on these patients.Therefore,here we summarized the research progress of the effects of VD supplementation on glycemic control and adverse maternal-neonatal outcomes in GDM patients,in an effort to guide the clinical VD supplementation during pregnancy.

Key words: vitamin D, gestational diabetes mellitus, vitamin D supplementation, adverse maternal-neonatal outcome

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