中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2021, Vol. 43 ›› Issue (4): 634-641.doi: 10.3881/j.issn.1000-503X.13315

• 综述 • 上一篇    下一篇

盘状蛋白结构域受体1在乳腺癌及其他恶性肿瘤中的研究进展

陈力,朱梦柳,孔祥溢,王翔宇,王仲照,方仪,王靖()   

  1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院 北京协和医学院 肿瘤医院乳腺外科 北京 100021
  • 收稿日期:2020-08-26 出版日期:2021-08-30 发布日期:2021-09-03
  • 通讯作者: 王靖 E-mail:wangjing@cicams.ac.cn
  • 基金资助:
    国家自然科学基金(81872160);北京市自然科学基金(7191009)

Research Progress of Discoidin Domain Receptor 1 in Breast Cancer and Other Malignant Tumors

CHEN Li,ZHU Mengliu,KONG Xiangyi,WANG Xiangyu,WANG Zhongzhao,FANG Yi,WANG Jing()   

  1. Department of Breast Surgical Oncology,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,CAMS and PUMC,Beijing 100021,China
  • Received:2020-08-26 Published:2021-08-30 Online:2021-09-03
  • Contact: WANG Jing E-mail:wangjing@cicams.ac.cn
  • Supported by:
    National Natural Science Foundation of China(81872160);Natural Science Foundation of Beijing(7191009)

摘要:

盘状蛋白结构域受体1(DDR1)是受体酪氨酸激酶重要家族成员之一,可以与其配体胶原蛋白特异性结合,导致位于胞内区的酪氨酸激酶缓慢而持续的磷酸化,而异常的酪氨酸激酶的活化与肿瘤的发生发展、炎性反应、纤维化等相关。DDR1参与细胞的黏附、迁移、增殖、分泌细胞因子及细胞外基质的重塑,在人体多种病理生理过程中起到重要作用。本文主要综述DDR1在乳腺癌及其他恶性肿瘤的研究进展,以期为乳腺癌及其他肿瘤的防治提供新的理论依据。

关键词: 盘状蛋白结构域受体1, 受体酪氨酸激酶, 信号通路, 肿瘤, 乳腺癌

Abstract:

Discoidin domain receptor 1(DDR1)is a critical member of the receptor tyrosine kinase family.It may be related to tumor invasion and metastasis,and the abnormal activation of DDR1 can lead to the occurrence and development of malignant tumors,inflammation,and fibrosis.DDR1 are involved in cell adhesion,migration,proliferation,secretion of cytokines,and remodeling of extracellular matrix,thus playing a critical role in various pathophysiological processes of the human body.In this review,we demonstrate the research progress of DDR1 in breast cancer and other malignant tumors,in order to provide a new theoretical basis for the prevention and treatment of breast cancer and other tumors.

Key words: discoidin domain receptor 1, receptor tyrosine kinase, signaling pathway, tumor, breast cancer

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