中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2012, Vol. 34 ›› Issue (3): 258-261.doi: 10.3881/j.issn.1000-503X.2012.03.013

• 论著 • 上一篇    下一篇

甲状腺球蛋白抗体在甲状腺乳头状癌131I治疗后的转阴时间及其影响因素

李田军1,林岩松2,梁 军1,李 方2   

  1. 1青岛大学医学院附属医院肿瘤科,青岛 266003
    2中国医学科学院 北京协和医学院 北京协和医院核医学科,北京 100730
  • 收稿日期:2011-08-22 修回日期:2012-06-30 出版日期:2012-06-29 发布日期:2012-06-29
  • 通讯作者: 林岩松 电话:010-69155605;梁军 电话:0532-82913035 E-mail:linyansong68@yahoo.com.cn;
    梁 军 电话:0532-82913035,电子邮件: liangjun1959@yahoo.com.cn

Time to Disappearance of Thyroglobulin Antibodies and Influencing Factors in Patients with Papillary Thyroid Carcinoma

LI Tian-jun1, LIN Yan-song2, LIANG Jun1, LI Fang2   

  1. 1Department of Oncology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China
    2Department of Nuclear Medicine, PUMC Hospital,CAMS and PUMC, Beijing 100730, China
  • Received:2011-08-22 Revised:2012-06-30 Online:2012-06-29 Published:2012-06-29

摘要: 目的 探讨阳性甲状腺球蛋白抗体(TgAb)在甲状腺乳头状癌131I治疗后的转阴时间及其影响因素。方法 回顾性分析64例经过甲状腺全切术及行131I治疗的甲状腺乳头状癌(PTC)患者的临床资料,根据是否伴随桥本甲状腺炎(HD)分为不伴(n=37) 和伴HD(n=27)两组。所有患者TgAb1(131I治疗前的TgAb水平)均高于正常值范围。应用生存分析的统计学方法观察总体阳性率随时间的变化并对两组进行比较。结果 两组TgAb转阴的中位时间差异无统计学意义(9.0个月比10.4个月,P=0.395)。Cox回归分析结果显示,TgAb转阴时间与TgAb1有关[偏回归系数(B)=-0.004,P=0.001],与年龄(B=-0.018,P =0.362)、性别(B=0.644,P=0.320)、HD(B=0.341,P=0.372)无关。结论 131I治疗前的TgAb水平对其转阴时间有显著影响,TgAb水平越高清除越慢。

关键词: 乳头状甲状腺癌, 甲状腺球蛋白抗体, 131I治疗

Abstract: Objective To investigate the time to disappearance of thyroglobulin antibodies (TgAb) and its influencing factors in papillary thyroid carcinoma (PTC) patients with positive TgAb after radioiodine (131I) ablation. Methods We retrospectively analyzed the clinical data of 64 PTC patients who had undergone a total thyroidectomy and subsequent 131I therapy. Patients were divided into two groups according to the presence of concurrent Hashimoto thyroiditis (HD). TgAb1 (TgAb levels determined before 131I therapy) were above the normal thresholds in all patients. The method of survival analysis (including Life tables and Cox Regression analysis) was used to assess the time to disappearance of TgAb and its influencing factors. Results The median time to disappearance of positive TgAb (9.0 months vs. 10.4 months, P=0.923) showed no significant difference between these two groups. Cox Regression analysis showed that, among the potential influencing factors including TgAb [partial regression coefficient (B)=-0.004, P=0.001], age(B=-0.018, P=0.362), sex (B=0.644, P=0.320) and HD (B=0.341, P=0.372), only TgAb1 was correlated with the TgAb negative conversion time. Conclusions TgAb1 has remarked influence on the time to disappearance of positive TgAb in PTC patients. Patients with a higher TgAb need longer time to achieve negative conversion.

Key words: papillary thyroid cancer, thyroglobulin antibodies, radioidine therapy

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