中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2012, Vol. 34 ›› Issue (5): 437-442.doi: 10.3881/j.issn.1000-503X.2012.05.001

• 论著 •    下一篇

全身磁共振弥散加权成像与生长抑素受体显像在瘤源性骨质软化症的应用比较

李烁1,薛华丹1,姜艳2,夏维波2,景红丽3,陈黎波3,孙非4,金征宇1   

  1. 中国医学科学院 北京协和医学院 北京协和医院 1放射科 2内分泌科 3核医学科, 北京 1007304通用电气医疗集团磁共振产品部, 北京 100172
  • 收稿日期:2012-07-17 修回日期:2012-11-07 出版日期:2012-10-31 发布日期:2012-10-31

Comparison of Whole Body Diffusion Weighted Magnetic Resonance Imaging and Somatostatin Receptor Scintigraphy for Oncogenic Osteomalacia

LI Shuo1, XUE Hua-dan1, JIANG Yan2, XIA Wei-bo2, JING Hong-li3, CHEN Li-bo3, SUN Fei4, JIN Zheng-yu1   

  1. 1Department of Radiology,2Department of Endocrinology,3Department of Nuclear Medicine,PUMC Hospital, CAMS and PUMC, Beijing 100730, China4MR Modality, General Electric Healthcare, Beijing 100172, China
  • Received:2012-07-17 Revised:2012-11-07 Online:2012-10-31 Published:2012-10-31

摘要: 目的 比较全身磁共振弥散加权成像(WB-DWI)和生长抑素受体显像(SRS)在发现及定位瘤源性骨质软化症患者致病瘤灶的准确性。方法 6例临床疑诊瘤源性骨质软化症的患者, 均于2周内分别行WB-DWI及SRS检查,评价两种检查方法发现致病瘤灶的价值,并以手术切除的病理诊断作为金标准,比较两者的敏感性、特异性及准确性。结果 手术病理证实的致病瘤灶包括软组织肿瘤2例(血管脂肪瘤及间叶组织肿瘤各1例)及骨肿瘤1例(恶性神经纤维瘤)。WB-DWI和SRS发现瘤源性骨质软化症患者致病瘤灶的敏感性、特异性及准确性分别为:WB-DWI: 33.33%、100%、66.67%;SRS: 33.33%、66.67%、50%。两种方法比较差异无统计学意义(P>0.05)。结论 对于成年的骨质软化症患者,应选择WB-DWI及SRS检查以寻找致病瘤灶,两者相互补充, 为临床提供更加全面的信息。

关键词: 磁共振弥散加权成像, 全身成像, 生长抑素受体显像, 骨质软化症

Abstract: Objective To compare the accuracy of whole body diffusion weighted magnetic resonance imaging (WB-DWI) with that of somatostatin receptor scintigraphy (SRS) in the detection and localization of the lesions in patients with oncogenic osteomalacia (OOM). Methods Totally 6 patients with clinically suspected oncogenic osteomalacia were enrolled. All of them underwent WB-DWI and SRS within 2 weeks to evaluate the possible presence of tumors that lead to osteomalacia. Surgical and pathological findings were considered as the gold standard. The sensitivity, specificity, and accuracy were calculated. Results Pathology confirmed the diagnosis of two soft tissue tumors (including 1 angiolipoma and 1 mensenchumal tumor) and one bone tumor of malignant neurofibroma. The sensitivity, specificity, and accuracy in the identification of lesions in patients with oncogenic osteomalacia were 33.33%, 100%, 66.67% for WB-DWI and 33.33%, 66.67%, 50% for SRS (P>0.05). Conclusion For adult patients with osteomalacia, WB-DWI and SRS can provide mutually supportive data and be used for identifying potential oncogenic osteomalacia.

Key words: diffusion weighted magnetic resonance imaging, whole body imaging, somatostatin receptor scintigraphy, osteomalacia

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