中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2012, Vol. 34 ›› Issue (5): 503-508.doi: 10.3881/j.issn.1000-503X.2012.05.012

• 论著 • 上一篇    下一篇

表观弥散系数值与Ki-67在胶质瘤诊断中的相关性

殷悦,佟丹,刘晓云,袁婷婷,闫昱竹,马越,赵瑞   

  1. 吉林大学 第一临床医院放射科,长春 130021
  • 收稿日期:2012-08-15 修回日期:2012-11-07 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 佟 丹 电话:0431-88782519,电子邮件:tongdan1968@126.com E-mail:tongdan1968@126.com

Correlation of Apparent Diffusion Coeffcient with Ki-67 in the Diagnosis of Gliomas

YIN Yue,TONG Dan,LIU Xiao-yun,YUAN Ting-ting,YAN Yu-zhu,MA Yue,ZHAO Rui   

  1. Department of Radiology,the First Affiliated Hospital of Jilin University,Changchun 130021,China
  • Received:2012-08-15 Revised:2012-11-07 Online:2012-10-31 Published:2012-10-31

摘要:

目的 探讨表观弥散系数(ADC)值与Ki-67在胶质瘤诊断中的相关性。方法 对76例胶质瘤患者术前进行常规磁共振检查、增强扫描检查及弥散加权成像扫描,测量肿瘤实质部分及相应对侧正常脑白质的ADC值,并计算其相对ADC(rADC)值,分析ADC值及rADC值与胶质瘤病理分级的关系。采用免疫组织化学染色方法对76例胶质瘤的Ki-67表达进行观察,测定Ki-67标记指数,分析ADC值与Ki-67表达程度诊断胶质瘤的相关性。结果 高级别胶质瘤肿瘤实质部分ADC值和rADC值明显低于低级别胶质瘤,即胶质瘤肿瘤实质部分ADC值及rADC值与肿瘤的恶性度呈负相关(r=-0.898,r=-0.868; P均<0.01);高级别胶质瘤中Ki-67的表达程度高于低级别胶质瘤,Ⅲ、Ⅳ级胶质瘤Ki-67标记指数分别为(29.48±19.78)%和(31.21±17.50)%,均高于低级别(Ⅰ、Ⅱ级)胶质瘤(2.33±2.20)%,差异均有统计学意义(P<0.01),但Ⅲ、Ⅳ级胶质瘤间Ki-67 标记指数差异无统计学意义(P>0.05);Ki-67表达程度与肿瘤实质部分ADC值及rADC值呈负相关(r=-0.627,r=-0.607;P<0.01)。结论 胶质瘤瘤体实质区ADC值和rADC值对胶质瘤病理分级诊断具有重要意义,根据胶质瘤实质部分ADC值及rADC值的测量,可间接评估肿瘤的增殖程度及恶性程度。

关键词: 胶质瘤, 弥散加权成像, 表观弥散系数, Ki-67

Abstract:

Objective To study the correlation between apparent diffusion coefficient (ADC) and Ki-67, a marker of tumor activity, in the diagnosis of gliomas. Methods Conventional magnetic resonance imaging (MRI), enhanced scanning, and diffusion-weighted imaging were performed in 76 patients with pathologically confirmed gliomas. The ADC values were measured at tumor parenchyma and the corresponding contralateral normal brain. The relatively ADC (rADC) values of the tumor parenchyma were calculated. The correlation of the ADC values with tumor grades was analyzed. The expression of Ki-67 was detected by immunohistochemical staining. The correlation between ADC value and Ki-67 in the diagnosis of gliomas was analyzed. Results The ADC values and rADC values of high-grade gliomas were significantly lower than those of low-grade gliomas. The ADC values of tumor parenchyma were inversely associated with the degree of malignancy of the gliomas(r=-0.898, r=-0.868; P<0.01). The expression of Ki-67 was significantly higher in high-grade gliomas than that in low-grade gliomas. The Ki-67 labeling index in grade Ⅲ and Ⅳ gliomas were (29.48±19.78)% and (31.21±17.50)%, respectively. Both of them were significantly higher than Ki-67 labeling index in low-grade (grade Ⅰ and Ⅱ) gliomas [(2.33±2.20)%] (P<0.01). Nevertheless, the Ki-67 labeling index showed no significant difference between grade Ⅲ and Ⅳ gliomas (P>0.05). The expression of Ki-67 was negatively correlated with the ADC values and rADC values in tumor parenchyma (r=-0.627, r=-0.607; P<0.01). Conclusion The ADC and rADC values of tumor parenchyma can indirectly reflect the proliferation and malignancy of gliomas and therefore can be useful for the grading of glioma.

Key words: gliomas, diffusion weighted imaging, apparent diffusion coefficient, Ki-67

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