中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2013, Vol. 35 ›› Issue (1): 36-39.doi: 10.3881/j.issn.1000-503X.2013.01.007

• 论著 • 上一篇    下一篇

GIRK4基因在肥胖大鼠肾脏组织的表达

康永安,胡燕荣,高莉,杨海,李南方   

  1. 新疆维吾尔自治区人民医院高血压中心 新疆高血压研究所,乌鲁木齐 830001
  • 收稿日期:2012-03-19 出版日期:2013-03-07 发布日期:2013-03-07
  • 通讯作者: 李南方 电话:0991-8564816,电子邮件:lnanfang2010@sina.com E-mail:lnanfang2010@sina.com
  • 基金资助:
    国家自然科学基金(81160109)

Expression of GIRK4 Gene in Kindey Tissues of Obese Rat

KANG Yong-an, HU Yan-rong, GAO Li, YANG Hai, LI Nan-fang   

  1. Hypertension Center of the Peoples Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumqi 830001, China
  • Received:2012-03-19 Online:2013-03-07 Published:2013-03-07
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81160109)

摘要: 目的 研究GIRK4基因在正常与肥胖大鼠肾脏组织表达水平的差异。方法 采用饮食诱导的方法构建肥胖大鼠模型,Western blot技术对正常组与肥胖组大鼠肾脏组织GIRK4蛋白表达进行定量分析。结果 肥胖组大鼠肾脏组织GIRK4蛋白相对表达量为1.75±0.42,明显低于正常组大鼠的3.37±0.68(P<0.05)。结论 肥胖大鼠肾脏组织GIRK4蛋白表达降低。   

关键词: GIRK4基因, 大鼠, 肾脏组织

Abstract: Objective To investigate the expression of GIRK4 gene in the kidney tissues of obese rats. Methods Obese rat models were established using diet-induced method. The GIRK4 protein expression in kidney tissues was determined in 20 obese rats and 10 normal rats using Western blot analysis. Results The relative expression level of GIRK4 protein in the kidney tissues of obese rat (1.75±0.42) was significantly lower than that in normal rats (3.37±0.68, P<0.05). Conclusion GIRK4 has a low protein expression in the kidney tissues of obese rat.

Key words: GIRK4 gene, rat, kidney tissue

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