中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2013, Vol. 35 ›› Issue (4): 462-465.doi: 10.3881/j.issn.1000-503X.2013.04.020

• 综述 • 上一篇    下一篇

肥胖症肠道菌群与炎症的研究进展

曹战江,于健春,康维明,马志强   

  1. 中国医学科学院 北京协和医学院 北京协和医院基本外科,北京 100730
  • 收稿日期:2012-12-05 出版日期:2013-08-30 发布日期:2013-08-30
  • 通讯作者: 于健春 电话:01069152213,电子邮件:yu-jch@163.com
  • 基金资助:
    卫生部内分泌重点实验室基金(2009301)、中国医学科学院北京协和医院青年基金(2009123)和中央保健专项资金科研课题(B2009A094)

Research Advances in the Gut Microbiota and Inflammation in Obesity

CAO Zhan-jiang,YU Jian-chun,KANG Wei-ming,MA Zhi-qiang   

  1. Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2012-12-05 Online:2013-08-30 Published:2013-08-30
  • Contact: YU Jian-chun Tel:01069152213,E-mail:yu-jch@163.com
  • Supported by:
    Supported by the Ministry of Health Key Laboratory of Endocrine Foundation(2009301),the Youth Foundation of PUMC Hospital(2009123),and the Special Fund of the Central Health Care(B2009A094)

摘要: 人体肠道内存在着多种多样的菌群,研究表明这些肠道菌群在肥胖发生过程中非常重要。肠道菌群调节宿主的能量吸收及营养代谢,肠道无菌小鼠在喂养高脂饮食时,体重增加不如正常小鼠明显,说明肠道菌群增加了宿主从肠道吸收的热量。肠道菌群改变产生过量的脂多糖(LPS),LPS入血引发炎症反应,促进高脂饮食导致的肥胖及代谢综合征。肠道菌群通过降低肠黏膜的Fiaf表达,增加脂肪在内脏的沉积。不同免疫状态对肠道菌群也有影响。肠道菌群成为肥胖发生的环境因素,与宿主、饮食等相互作用,调节着宿主的能量代谢。使用一些抗生素或益生菌可以改变肠道菌群,改善代谢综合征,这为治疗肥胖提供了可能的方向。

关键词: 肥胖, 肠道菌群, 炎症, 代谢紊乱

Abstract: Human gut microbiota plays a key role in the development of obesity.Intestinal flora can regulate energy absorption and nutrition metabolism,increasing the energy harvesting from diet.Alteration of gut flora produces excessive lipopolysaccharide,which,when absorbed into the blood,can induce inflammatory reactions and promote the high-fat diet-associated obesity and metabolic syndrome.Intestinal flora increase visceral fat deposition by lowering the expression of Fiaf in intestinal mucosa.Different immune status also affects the intestinal flora.The gut microbiota is hypothesized to be an environmental factor that contributes to obesity;by interacting with factors such as host and diet,it adjusts the energy metabolism.Antibiotics or probiotics may alter the composition of intestinal microflora and improve the metabolic syndrome,and thus provides new treatment options.

Key words: obesity, gut microbiota, inflammation, metabolic disturbance