中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2015, Vol. 37 ›› Issue (4): 430-434.doi: 10.3881/j.issn.1000-503X.2015.04.011

• 论著 • 上一篇    下一篇

门诊口服糖皮质激素药物超适应证使用情况分析

唐彦, 尚楠, 杜小莉(), 张钰宣, 王德志   

  1. 中国医学科学院 北京协和医学院 北京协和医院药剂科,北京 100730
  • 收稿日期:2014-06-06 出版日期:2015-05-25 发布日期:2015-08-31
  • 作者简介:

    通信作者:杜小莉 电话:010-69156537,电子邮件:duxiaolipumch@163.com

Evaluation of Off-label Use of Oral Glucocorticoids in Outpatients

Yan TANG, Nan SHANG, Xiao-li DU(), Yu-xuan ZHANG, De-zhi WANG   

  1. Department of Pharmacy,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2014-06-06 Online:2015-05-25 Published:2015-08-31

摘要: 目的

分析门诊口服糖皮质激素药物的超适应证使用情况。

方法

从本院信息系统调取2012年1月1日至6月30日门诊口服糖皮质激素药物的全部处方数据。用Excel软件对药品使用的数量、患者情况、诊断等逐一进行统计分析,将诊断与药品说明书及国内外指南包括的适应证进行比对。

结果

16.53%存在超适应证用药,超适应证用药比例最高的是醋酸地塞米松片(60.50%)。多数超适应证用药具有证据支持,如多发性骨髓瘤、重症肌无力等;少数为不合理用药,如癫痫、突发性耳聋。

结论

仍需进一步规范口服糖皮质激素药物的超适应证用药,以提高用药的合理性和安全性。

关键词: 糖皮质激素, 门诊, 超适应证, 合理用药

Abstract: Objective

To investigate the off-label use of oral glucocorticoids in outpatients.

Methods

The information of outpatient glucocorticoids prescriptions from January 1st to June 30th in 2012 were collected from the information system in our hospital,then the software of Excel was employed to statistically analyze the data including the amount of drugs used in different departments,as well as the age,sex,and diagnosis of the patients. The diagnoses were compared with those included in the labels approved by China Food and Drug Administration and US Food and Drug Administration and domestic and foreign guidelines.

Results

It was found that 16.53% of the cases were off-label use,and dexamethasone had the highest proportion(60.50%)of off-label use. Most of the off-label use had evidence support,such as multiple myeloma and myasthenia gravis,while some cases did not,such as epilepsy and sudden deafness.

Conclusion

The management of off-label use should be further strengthened to promote the safe and rational use of glucocorticoids.

Key words: glucocorticoid, outpatient, off-label indications, rational drug use

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