中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2016, Vol. 38 ›› Issue (2): 182-186.doi: 10.3881/j.issn.1000-503X.2016.02.010

• 论著 • 上一篇    下一篇

纯磨玻璃密度肺腺癌内血管异常CT表现与病理亚型的相关性

杨越清1, 吕喆2, 高杰3, 金鑫1, 吴芳1, 金梅1, 吴坚1, 赵绍宏1()   

  1. 1中国人民解放军总医院放射诊断科,北京 100853
    2北京大学 首钢医院放射诊断科,北京 100041
    3中国人民解放军总医院病理科,北京 100853
  • 收稿日期:2015-08-07 出版日期:2016-02-15 发布日期:2016-04-10
  • 作者简介:

    通信作者:赵绍宏 电话:010-66939590,电子邮件:zhaoshaohong@aliyun.com

  • 基金资助:
    中国人民解放军总医院临床科研扶持基金(2012FC-TSYS-1025)

Correlations between Vessel Changes and the Histopathologic Subtypes of Lung Adenocarcinoma with Pure Ground-glass Nodule on Computed Tomography

Yue-qing YANG1, Zhe LÜ2, Jie GAO3, Xin JIN1, Fang WU1, Mei JIN1, Jian WU1, Shao-hong ZHAO1()   

  1. 1Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China
    2Department of Radiology,Shougang Hospital of Peking University,Beijing 100041,China
    3Department of Pathology,Chinese PLA General Hospital,Beijing 100853,China
  • Received:2015-08-07 Online:2016-02-15 Published:2016-04-10
  • Supported by:
    Supported by the Clinical Research Support Fund of Chinese PLA General Hospital (2012FC-TSYS-1025)

摘要:

目的 探讨CT上纯磨玻璃密度结节(pGGN)肺腺癌内血管异常改变与病理亚型的相关性。方法 收集107例(116个病灶)经病理证实的pGGN肺腺癌患者的CT影像与病理资料,根据血管在pGGN内的表现(包括血管聚集或/和增粗、扭曲)分成两组:无血管改变组和有血管改变组;肺腺癌的病理分型为3组:浸润前病变组、微浸润腺癌组和浸润腺癌组。采用卡方检验分析血管异常改变与病理亚型的关系,血管异常改变与病灶大小及密度之间的关系分别采用秩和检验和t检验。结果 116个pGGN肺腺癌中,浸润前病变组25个、微浸润腺癌组29个、浸润腺癌组62个。其中无血管改变和出现血管改变分别为21和4、14和15、16和46个。浸润前组、微浸润腺癌组与浸润腺癌组血管改变的差异有统计学意义(P=0.000);血管改变与pGGN的直径差异有统计学意义(P=0.000),与pGGN密度无统计学意义(P=0.826)。结论 pGGN肺腺癌中出现血管异常改变与病变浸润性有相关性,且与pGGN的大小相关,而与病变的密度无关。

关键词: 肺肿瘤, 腺癌, 病理, 计算机断层成像

Abstract:

Objective To investigate the correlations between vessel changes and the histopathologic subtypes of lung adenocarcinoma with pure ground-glass nodule (pGGN) on computed tomography (CT). Methods Totally 107 patients (116 lesions) with lung adenocarcinomas with pGGN who had undergone curative resection were included. Vessel changes included vascular convergence and/or vessel dilation or distortion within the pGGN. According to the vessel appearances within the pGGN,all patients were categorized into two groups:no change group and change group. Pearson chi-square test was used to analyze the relationships between vessel changes and histopathologic subtypes. Mann-Whitney rank test and t-test were used to identify the relationship of vessels changes with pGGN density and diameter. Results Among these 116 pGGNs,there were 21 without vessel changes and 4 with vessel changes in 25 preinvasive lesions;14 without vessel changes and 15 with vessel changes in 29 minimally invasive adenocacinomas;16 without vessel changes and 46 with vessel changes in 62 invasive lung adenocarcinomas. There were statistically significant differences of vessel changes (P=0.000) among histopathologic subtypes. The lesion diameter was significantly different between these two groups (P=0.000),while the lesion density showed no significant difference (P=0.826). Conclusion Vessel changes may indicate the invasiveness of lung adenocarcinoma with pGGNs and are related with the lesion diameter.

Key words: lung neoplasms, adenocarcinoma, pathology, tomography X-ray,computed

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