中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2016, Vol. 38 ›› Issue (2): 187-191.doi: 10.3881/j.issn.1000-503X.2016.02.011

• 论著 • 上一篇    下一篇

产后抑郁母代对子代小鼠青少年期抑郁发病的影响

吴如燕, 陆彩, 夏宝妹, 薛文达, 陶伟伟, 陈刚()   

  1. 南京中医药大学 基础医学院转化系统生物学与神经科学实验中心,南京 210023
  • 收稿日期:2015-06-23 出版日期:2016-02-15 发布日期:2016-04-10
  • 作者简介:

    通信作者:陈 刚 电话:025-85811160,电子邮件:chengang@njucm.edu.cn

  • 基金资助:
    江苏省自然基金(BK20140961,BK20140962)和南京中医药大学青年基金(12XZR04,13XZR06)

Effect of Postpartum Depression on Adolescent Depression of Mice Offspring

Ru-yan WU, Cai LU, Bao-mei XIA, Wen-da XUE, Wei-wei TAO, Gang CHEN()   

  1. Center for Translational Systems Biology and Neuroscience,School of Basic Biomedical Science,Nanjing University of Chinese Medicine,Nanjing 210023,China
  • Received:2015-06-23 Online:2016-02-15 Published:2016-04-10
  • Supported by:
    Supported by the Natural Science Foundation of Jiangsu Province (BK20140961,BK20140962) and Nanjing University of Chinese Medicine Funds for Young Scientists (12XZR04,13XZR06)

摘要:

目的 探讨产后抑郁母代对子代小鼠青少年期抑郁发病的影响。方法 48只Balb/c雌鼠按随机数字表法分为对照组及应激组,每组24只。对照组不予任何刺激,应激组给予慢性应激3周:束缚(6 h/d)联合光照24 h(2次/周)。应激结束后,应激组分为3组,每组8只,分别于造模后、造模后正常饲养3周后、分娩3周后予以行为测量,以验证产后抑郁造模成功。正常母代与造模成功的产后抑郁母代所生的F1代雄鼠为:正常对照子代组(CTL-F1)及产后抑郁子代组(PPD-F1)。3~4周龄CTL-F1及PPD-F1雄鼠糖水偏好、强迫游泳及新奇环境摄食实验测量子代的抑郁样行为。结果 PPD-F1代3及4周龄体质量显著低于正常对照组(CTL-F1)(P=0.000,P=0.002);糖水偏好显著下降(P=0.000);强迫游泳不动时间显著延长(P=0.001);摄食潜伏期显著延长(P=0.000),并且单位体质量摄食量显著下降(P=0.005)。结论 产后抑郁子代可能更易患抑郁症,最早可能发病于青少年期。

关键词: 产后抑郁子代, 抑郁症, 青少年期

Abstract:

Objective To study the effect of postpartum depression (PPD) on adolescent depression of mice offspring. Methods Totally 48 Balb/c female mice were equally randomized into control group and stress group. Control group was not given any stress,whereas stress group were given chronic stress:constraining (6 h/d) combined with light stimulation for 24 hours(twice a week). The stress group was divided into 3 groups to measue the animals’ behaviors immediately after modeling,three weeks after modeling,and three weeks after delivery to test whether the PPD models were successfully constructed. The first generation (F1) of normal mothers and PPD-born F1 were as follows:control group (CTL-F1) and PPD offspring group (PPD-F1). The 3-4-week-old male CTL-F1 and PPD-F1 mice (n=8 each) were weighed,and received sucrose preference test,forced swimming test,and novelty-supressed feeding test to measure the depression-like behaviors. Results The 3-and 4-week-old PPD-F1 had significantly lower body mass than CTL-F1 (P=0.000,P=0.002). Also,the sucrose preference significantly decreased (P=0.000),the forced swimming immobility time significantly increased (P=0.001),the latency to feed significantly increased (P=0.000),while food intake significantly decreased (P=0.005). Conclusion PPD offspring may be more susceptible to depression,with a possible eary onset in adolescence.

Key words: postpartum depression offspring, depression, adolescence

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