中国医学科学院学报

高级检索
中国医学科学院学报

中国医学科学院学报 ›› 2016, Vol. 38 ›› Issue (2): 192-197.doi: 10.3881/j.issn.1000-503X.2016.02.012

• 论著 • 上一篇    下一篇

中老年回汉族人群胰岛素抵抗及β细胞功能与脂代谢的关系

李淑亚1, 姜敏2(), 姚天宇1, 程羽萱1, 范雅洁1, 刘旭颖1, 张金玲1, 刘兰3, 王志忠3, 马玉英4, 扈学琴4, 王盼盼4, 于晶晶2, 马荣2, 黄琦2   

  1. 1宁夏医科大学 研究生院,银川 750004
    2宁夏医科大学 总医院暨生物芯片北京国家工程研究中心宁夏分中心,银川 750004
    3宁夏医科大学 公共卫生学院流行病与卫生统计学系,银川 750004
    4宁夏医科大学 总医院体检中心,银川 750004
  • 收稿日期:2015-07-01 出版日期:2016-02-15 发布日期:2016-04-10
  • 作者简介:

    通信作者:姜 敏 电话:0951-6744181,电子邮件:minjiang_nx@163.com

  • 基金资助:
    国家自然科学基金(81160049)

Association of Insulin Resistance and β Cell Function with Lipid Metabolism in Middle-aged and Elderly Hui and Han Populations

Shu-ya LI1, Min JIANG2(), Tian-yu YAO1, Yu-xuan CHENG1, Ya-jie FAN1, Xu-ying LIU1, Jin-ling ZHANG1, Lan LIU3, Zhi-zhong WANG3, Yu-ying MA4, Xue-qin HU4, Pan-pan WANG4, Jing-jing YU2, Rong MA2, Qi HUANG2   

  1. 1 Graduate School of Ningxia Medical University,Yinchuan 750004,China
    2General Hospital of Ningxia Medical University,National Engineering Research Center for Beijing Biochip Technology,Sub-center in NingXia,Yinchuan 750004,China
    3 Department of Epidemiology and Biostatistics,School of Public Health of Ningxia Medical University,Yinchuan 750004,China
    4 Health Examination Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China
  • Received:2015-07-01 Online:2016-02-15 Published:2016-04-10
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81160049)

摘要:

目的 对宁夏城市社区回汉族中老年人群的胰岛素抵抗及β细胞功能与体质量指数及血脂等影响因素进行关联性对比研究。方法 选取宁夏城市地区40岁以上的社区调查者共1 000例,回汉比例1∶2。测量身高、体质量、腰围、臀围;三酰甘油 (TG)、总胆固醇(TC)、血尿酸(BUA)、血糖、胰岛素,计算体质量指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(IR)、胰岛素敏感指数(IAI)、β细胞功能指数(HBCI)。结果 回族的BMI、WHR、IAI、HBCI和糖尿病的患病比例均显著高于汉族(P<0.01),但是BUA、血糖、TC、IR均低于回族(P<0.01)。回族中TG、BMI、WHR、BUA与IR呈正相关(r分别为0.234、0.193、0.143、0.129,P<0.01),与IAI呈负相关(r分别为-0.234、-0.193、-0.143、-0.129,P<0.01),TC与HBCI呈负相关(r为-0.169,P<0.01);汉族中TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.140、0.257、0.288、0.163、0.104,P<0.01),与IAI呈负相关(r分别为-0.140、-0.257、-0.288、-0.163、-0.104,P<0.01),BMI与HBCI呈负相关(r为-0.111,P<0.01)。校正性别、民族、年龄因素后,TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.109、0.256、0.253、0.139、0.142,P<0.01),与IAI呈负相关(r分别为-0.109、-0.256、-0.253、-0.139、-0.142,P<0.01),TC、BMI与HBCI呈负相关(r=-0.113,r=-0.086,P<0.01)。多元回归分析显示TG、BMI与IR、IAI独立相关(r分别为0.218、0.182、-0.218、-0.182),TC、BMI与HBCI独立相关(r分别为-0.113、-0.086)。结论 宁夏地区中老年人TC、TG、BMI、WHR、BUA和IR、IAI、HBCI的分布特征及其之间的关系存在着回汉族差异。校正性别、民族、年龄因素后,BMI、WHR、TC、TG、BUA与IR、IAI显著相关,BMI、TC与HBCI显著相关,TC、BMI可能对β细胞的分泌功能影响较大,而TG、BMI则主要与胰岛素抵抗及胰岛素敏感性相关。

关键词: 胰岛素抵抗指数, β, 细胞功能指数, 体质量指数, 腰臀比, 胆固醇, 三酰甘油

Abstract:

Objective To explore the association of insulin resistance and β cell function with lipid metabolism in middle-aged and elderly Hui and Han populations. Methods A total of 1 000 subjects age over 40 years were recruited from five urban communities in Yinchuan and Wuzhong cities of Ningxia. The composition ratio between Hui and Han nationality was 1∶2. A questionnaire-based survey was performed. Physical examinations were carried out to measure the height,body mass,waistline,and hipline. The levels of triglyceride (TG),total cholesterol (TC),blood uric acid (BUA),fasting blood glucose and insulin were measured. The boby mass index (BMI),waist-hip ratio (WHR),and secretion related index including insulin resistance index (IR),insulin sensitivity index (IAI),and beta cell function index (HBCI) were calculated. Results The BMI,WHR,IAI,HBCI,and the prevalence rate of diabetes in Hui nationality were significantly higher than those in Han nationality (P<0.01). The levels of BUA,fasting blood glucose,TC,and IR in Han nationality were significantly lower than those in Hui nationality (P<0.01). In Hui populations,TG,BMI,WHR,and BUA were positively correlated with IR (r=0.234,r=0.193,r=0.143,and r=0.129,respectively;P<0.01) and were negatively correlated with IAI (r=-0.234,r=-0.193,r=-0.143,r=-0.129,respectively;P<0.01),whereas TC was negatively correlated with HBCI (r=-0.169,P<0.01). In Han populations,TC,TG,BMI,WHR,and BUA were positively correlated with IR (r=0.140,r=0.257,r=0.288,r=0.163,r=0.104,P<0.01) and negatively correlated with IAI (r=-0.140,r=-0.257,r=-0.288,r=-0.163,and r=-0.104,P<0.01),whereas BMI was negatively correlated with HBCI (r=-0.111,P<0.01). After the influential factors such as gender,nationality,and age were adjusted,the TC,TG,BMI,WHR,BUA levels were positively correlated with IR (r=0.109,r=0.256,r=0.253,r=0.139,and r=0.142,P<0.01) and negatively correlated with IAI(r=-0.109,r=-0.256,r=-0.253,r=-0.139,and r=-0.142,P<0.01). TC and BMI were negatively correlated with HBCI (r=-0.113,r=-0.086,P<0.01). TG and BMI were independently associated with IR and IAI (r=0.218,r=0.182,r=-0.218,r=-0.182),while TC and BMI were independently associated with HBCI (r=-0.113,r=-0.086). Conclusions The distributions of TC,TG,BMI,WHR,BUA,IR,IAI,and HBCI differ between Han and Hui populations. The development of insulin resistance is closely related with the increased levels of TC,TG,BMI,WHR,and BUA. However,the HBCI increases with the increased level of TC and BMI. TG and BMI may be related with insulin resistance. Also,TC and BMI may affect the secretion function of β cells.

Key words: insulin resistance index, beta cell function index, body mass index, waist-to-hip ratio, cholesterol, triglyceride

中图分类号: