中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2016, Vol. 38 ›› Issue (4): 464-469.doi: 10.3881/j.issn.1000-503X.2016.04.017

• 综述 • 上一篇    下一篇

尿外泌体在肾脏疾病的研究进展

陈沛沛, 秦岩(), 李雪梅   

  1. 中国医学科学院 北京协和医学院 北京协和医院肾内科,北京 100730
  • 收稿日期:2016-03-07 出版日期:2016-08-20 发布日期:2016-08-20
  • 作者简介:

    通信作者:秦 岩 电话:010-69155058,电子邮件:qinyanbeijing@126.com

  • 基金资助:
    国家自然青年科学基金(81100545)、北京市科委项目(D131100004713007、D09050704310901)和协和青年基金(3332016012)

Advances in the Urinary Exosomes in Renal Diseases

Pei-pei CHEN, Yan QIN(), Xue-mei LI   

  1. Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2016-03-07 Online:2016-08-20 Published:2016-08-20
  • Supported by:
    Supported by the National Natural Sciences Foundation for Young Scholar of China(81100545),State Commission of Science Technology of Beijing(D131100004713007,D09050704310901),and PUMC Youth Fund(3332016012)

摘要:

外泌体是细胞主动分泌到微环境中直径为30~100 nm的双层质膜结构的囊泡。随着技术的不断发展,人们发现外泌体可广泛分布于各种体液中,其含有的母细胞来源的蛋白质、核酸等物质不仅能反映来源细胞的生理状态,还可能在生理和疾病状态下的细胞间通讯过程中发挥重要作用。本文主要介绍尿外泌体的生物学特性及其可作为肾脏疾病的新兴生物学标志物、干预治疗目标和靶向治疗载体的潜力,概述目前存在的问题及展望该液体活检的临床应用前景。

关键词: 尿外泌体, 肾脏疾病, 液体活检, 生物学标志物, 靶向治疗载体

Abstract:

Cells secrete around 30-100 nm membrane-enclosed vesicles that are released into the extracellular spaceis termed exosomes(EXs). EXs widely present in body fluids and incorporated proteins,nucleic acids that reflect the physiological state of their cells of origin and they may play an important role in cell-to-cell communication in various physiological and disease processes. In this article we review the recent basic and clinical studies in urinary EXs in renal diseases,focusing on their biological characteristics and potential roles as new biological markers,intervention treatment goals,and targeted therapy vectors in renal diseases.However,some issues still exist;in particular,the clinical application of EXs as a liquid biopsy technique warrants further investigations.

Key words: urinary exosomes, renal diseases, liquid biopsy, biological markers, target therapy vector

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