中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2017, Vol. 39 ›› Issue (4): 499-505.doi: 10.3881/j.issn.1000-503X.2017.04.007

• 论著 • 上一篇    下一篇

性别及年龄对非酒精性脂肪肝患病情况及伴发疾病的影响

蔡美娟, 孔祥楠, 赵晓云()   

  1. 山东大学 齐鲁医院(青岛)检验医学中心,山东青岛 266035
  • 收稿日期:2016-05-25 出版日期:2017-08-10 发布日期:2017-08-20
  • 作者简介:

    通信作者:赵晓云 电话:0532-66850872,电子邮件:18561810828@126.com

  • 基金资助:
    山东省医药卫生科技发展计划(2014WS0130)

Influences of Gender and Age on the Prevalence and Complications of Nonalcoholic Fatty Liver Disease

Meijuan CAI, Xiangnan KONG, Xiaoyun ZHAO()   

  1. Laboratory Medicine Center of Qilu Hospital of Shandong University(Qingdao),Qingdao,Shandong 266035,China
  • Received:2016-05-25 Online:2017-08-10 Published:2017-08-20

摘要:

目的 调查年龄和性别对非酒精性脂肪肝(NAFLD)患病情况及伴发疾病的影响。方法 收集本院体检中心和门诊NAFLD患者8429例,进行问卷咨询、体格检查、血脂和血糖等检测以及肝脏实时超声检查。按照年龄将其分为青年组(年龄<45岁)、中年组(45≤年龄<60岁)和老年组(年龄≥60岁),并比较不同组别患者的临床和实验室指标。结果 随着年龄增长,NAFLD男性患者比例逐渐降低,而女性患者比例升高(P<0.01);NAFLD伴发各种代谢疾病比例在青年组、中年组和老年组中差异有统计学意义(P<0.01);除高脂血症外,3个年龄组中男性NAFLD伴发疾病比例均高于女性(P<0.01)。结论 NAFLD患者伴发代谢疾病比例与年龄和性别相关,这对NAFLD的预防和治疗具有一定的指导意义。

关键词: 非酒精性脂肪肝, 性别, 年龄, 代谢综合征

Abstract:

Objective To investigate the effects of gender and age on the prevalence and complications of nonalcoholic fatty liver disease(NAFLD). Methods A total of 8429 NAFLD patients were selected from the Health Check-up Center and Outpatient Departments of Qilu Hospital of Shandong University(Qingdao).The questionnaire-based survey,physical examinations,biochemical tests,and liver ultrasonography were performed for all cases.Patients were divided into young group(<45 years),middle aged group(45 years≤age<60 years),and old group(≥60 years)according to age,and the clinical features and laboratory findings were analyzed. Results The proportion of male patients gradually decreased with age,while the proportion of female patients increased(P<0.01);The incidences of metabolic diseases showed significant difference among young group,middle aged group,and old group(P<0.01).Except for hyperlipidemia,the proportion of male patients with NAFLD-accompanied metabolic symdrome was significantly higher than that of female patients in all three age groups(all P<0.01). Conclusions The prevalence of NAFLD-accompanied metabolic syndrome disease is associated with age and gender.This finding is useful for the prevention and treatment of NAFLD.

Key words: nonalcoholic fatty liver disease, gender, age, metabolic syndrome

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