中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2017, Vol. 39 ›› Issue (5): 682-687.doi: 10.3881/j.issn.1000-503X.2017.05.014

• 论著 • 上一篇    下一篇

超声光散射成像与PET-CT联合应用在乳腺癌诊断中的价值

王红燕1, 靳晓娜2, 姜玉新1(), 朱朝晖2, 徐颖3, 朱庆莉1, 戴晴1, 李建初1, 李方2, 孙强3   

  1. 1超声医学科, 中国医学科学院 北京协和医学院 北京协和医院,北京 100730
    2核医学科, 中国医学科学院 北京协和医学院 北京协和医院,北京 100730
    3乳腺外科, 中国医学科学院 北京协和医学院 北京协和医院,北京 100730
  • 收稿日期:2017-01-11 出版日期:2017-10-30 发布日期:2017-10-30
  • 作者简介:

    通信作者:姜玉新 电话:010-69155491,电子邮件:yuxinjiangxh@163.com

  • 基金资助:
    国家自然科学基金(81601517、81371557)

Clinical Values of Combined Diffused Optical Tomography and PET-CT in the Diagnosis of Breast Cancer

Hongyan WANG1, Xiaona JIN2, Yuxin JIANG1(), Zhaohui ZHU2, Ying XU3, Qingli ZHU1, Qing DAI1, Jianchu LI1, Fang LI2, Qiang SUN3   

  1. 1Department of Ultrasound, PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    3Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2017-01-11 Online:2017-10-30 Published:2017-10-30
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81601517,81371557)

摘要:

目的 探讨超声光散射成像(DOT) 与PET-CT联合应用在乳腺诊断中的价值。方法 对38例患者的40个病灶分别进行DOT和PET-CT检查,与病理结果对照,对比分析DOT及PET-CT在乳腺癌超声诊断中的敏感性、特异性、准确性、阳性预测值、阴性预测值。结果 DOT对乳腺癌诊断的敏感性为78.26%,特异性为76.47%,准确性为77.50%,阳性预测值为72.22%,阴性预测值为81.81%。PET-CT对乳腺癌诊断的敏感性为86.96%,特异性为82.35%,准确性为85.00%,阳性预测值为86.96%,阴性预测值为82.35%。联合应用DOT和PET-CT的敏感性为86.96%,特异性为94.12%,准确性为90.00%,阳性预测值为95.23%,阴性预测值84.21%。结论 DOT 和PET-CT 检查均为有效的诊断方法,联合应用DOT 和PET-CT 可以提高乳腺癌的诊断效能,提高诊断特异性、阳性预测值及准确性,减少不必要的活检,对临床治疗方案的选择及患者的预后具有重要意义。

关键词: 超声光散射成像, PET-CT, 乳腺癌

Abstract:

Objective To investigate the clinical values of combined diffused optical tomography (DOT) combined positron emission tomography-computed tomography (PET-CT) in the diagnosis of breast cancer. Methods We performed DOT and PET-CT examinations in 38 patients with 40 lesions and compared these images with the pathological results to analyze the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of these two techniques and their combination.Results The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value in diagnosing breast cancer were 78.26%,76.47%,77.50%,72.22%,and 81.81% for DOT,86.96%,82.35%,85.00%,86.96%,and 82.35% for PET-CT,and 86.96%,94.12%,90.00%,95.23%,and 84.21% for the combination of PET-CT and DOT.Conclusions DOT and PET-CT are both effective diagnostic methods for breast cancer.Combined DOT and PET-CT can improve the diagnostic efficacy in terms of specificity,positive predictive value,and accuracy.

Key words: diffused optical tomography, PET-CT, breast cancer

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