中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2007, Vol. 29 ›› Issue (3): 436-440.

• 综述 • 上一篇    下一篇

神经系统特异性转录因子Nhlh2的研究进展

胡 娟, 彭小忠   

  1. 中国医学科学院 北京协和医学院 基础医学研究所医学分子生物学国家重点实验室,北京 100005
  • 收稿日期:2007-01-22 修回日期:1900-01-01 出版日期:2007-06-30 发布日期:2007-06-30
  • 通讯作者: 彭小忠

Research Advances in Nervous System-specific Transcription Factor, Nhlh2

HU Juan, PENG Xiao-zhong   

  1. National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China
  • Received:2007-01-22 Revised:1900-01-01 Online:2007-06-30 Published:2007-06-30
  • Contact: PENG Xiao-zhong

摘要: 摘要:Nhlh2( nescient helix-loop-helix 2)基因,又名HEN2(HUA ENHANCER 2)和NSCL2(neuronal stem cell leukemia 2 )(或NSCL-2), 其编码蛋白是碱性螺旋-环-螺旋(bHLH)转录因子家族的新成员,在神经系统中尤其是神经内分泌组织中特异性表达。目前已在鸡、小鼠、大鼠、牛和人类等多种真核生物中发现其同源基因,该基因的功能研究主要集中在神经内分泌系统、视网膜发育和肿瘤等相关领域,对其分子调控机制的探询已经取得一些初步成果。本文将从Nhlh2的基因和编码蛋白的特性、表达时空、功能研究以及调控与被调控机制等方面对其研究进展进行综述,并对今后的研究提出了展望和思考。

关键词: 神经系统特异性转录因子, Nhlh2

Abstract: ABSTRACT:The protein encoded by gene Nhlh2 (nescient helix-loop-helix 2, also known as HEN2 or NSCL2) is a new member of basic helix-loop-helix (bHLH) transcription factor family and is specifically expressed in nervous system, especially in neuroendocrine tissue. The homologous genes of Nhlh2 have been found in many eukaryotic organisms such as chicken, mouse, rat, cattle, and human. The functional researches of Nhlh2 are mainly focused on neuroendocrine system, retina development, and tumors. Some preliminary results have been obtained in the investigation of molecular regulation mechanism. This article summarizes the recent research advances in Nhlh2.

Key words: nervous system specific transcription factor, ndld2