中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2021, Vol. 43 ›› Issue (3): 488-493.doi: 10.3881/j.issn.1000-503X.13717

• 病例报告 • 上一篇    下一篇

长期口服甲氨蝶呤导致口腔黏膜弥漫大B细胞淋巴瘤一例

刘彦权1,2,胡晓梅3,殷悦4,张浪辉2,付海英2,刘庭波2,沈建箴2()   

  1. 1赣南医学院第一附属医院/第一临床医学院,江西赣州 341000
    2福建医科大学附属协和医院 血液科,福州 350001
    3福建医科大学附属协和医院 病理科,福州 350001
    4福建医科大学附属协和医院 细胞形态室,福州 350001
  • 收稿日期:2021-01-09 出版日期:2021-06-30 发布日期:2021-07-09
  • 通讯作者: 沈建箴 E-mail:doctorsjz@163.com
  • 基金资助:
    国家自然科学基金(81300428);福建省血液医学中心建设项目(闽卫医政[2017]171号);国家及福建省临床重点专科建设项目(闽卫医函[2011]1018号、闽卫科教[2012]149号)

Oral Mucosal Diffuse Large B-cell Lymphoma Caused by Long-term Oral Methotrexate:Report of One Case

LIU Yanquan1,2,HU Xiaomei3,YIN Yue4,ZHANG Langhui2,FU Haiying2,LIU Tingbo2,SHEN Jianzhen2()   

  1. 1First Clinical Medical College,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000,China
    2Department of Hematology, Fujian Medical University Union Hospital,Fuzhou 350001,China
    3Department of Pathology, Fujian Medical University Union Hospital,Fuzhou 350001,China
    4Department of Cell Morphology, Fujian Medical University Union Hospital,Fuzhou 350001,China
  • Received:2021-01-09 Published:2021-06-30 Online:2021-07-09
  • Contact: SHEN Jianzhen E-mail:doctorsjz@163.com
  • Supported by:
    National Natural Sciences Foundation of China(81300428);Construction Project of Fujian Blood Center(Min[2017]171);National and Fujian Provincial Key Clinical Specialty Construction Project(Min[2011]1018,Min[2012]149)

摘要:

回顾性总结福建医科大学附属协和医院血液科收治的1例因类风湿关节炎(RA)长期服用甲氨蝶呤(MTX)导致原发口腔黏膜的弥漫大B细胞淋巴瘤(DLBCL)患者的临床病史资料,分析和探讨RA患者服用MTX后诱发特殊部位恶性淋巴瘤的临床特点、诊治及预后情况,旨在提高临床医师与病理科医师对少见其他医源性免疫缺陷相关淋巴增殖性疾病(MTX治疗相关DLBCL)的认识,为MTX治疗相关DLBCL的临床诊疗提供新的借鉴和参考。

关键词: 其他医源性免疫缺陷相关淋巴增殖性疾病, 免疫抑制剂, 甲氨蝶呤, 甲氨蝶呤相关淋巴组织增殖性疾病, 淋巴瘤, 结外淋巴瘤

Abstract:

A case of primary oral mucosal diffuse large B-cell lymphoma(DLBCL)due to long-term use of methotrexate(MTX)for the treatment of rheumatoid arthritis(RA)was admitted to the Department of Hematology,Fujian Medical University Union Hospital.We analyzed and discussed the clinical features,diagnosis and treatment,and prognosis of specific malignant lymphoma induced by MTX in this RA patient.Our purpose is to improve the awareness and knowledge of other iatrogenic immunodeficiency-associated lymphoproliferative disorders of clinicians and pathologists.This study provides a new reference for the clinical diagnosis and treatment of MTX-associated DLBCL.

Key words: other iatrogenic immunodeficiency-associated lymphoproliferative disorders, immunosuppressive agents, methotrexate, methotrexate-associated lymphoproliferative disorders, lymphoma, extranodal lymphoma

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