中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2020, Vol. 42 ›› Issue (6): 781-788.doi: 10.3881/j.issn.1000-503X.11985

• 论著 • 上一篇    下一篇

CT纹理分析与淋巴结阴性结直肠癌患者伴同时性远处转移的相关性分析

房玥,王国蓉,王志伟(),金征宇   

  1. 中国医学科学院 北京协和医学院 北京协和医院放射科,北京 100730
  • 收稿日期:2019-09-09 出版日期:2020-12-30 发布日期:2021-01-11
  • 通讯作者: 王志伟 E-mail:zhiweiwang1981@sina.com
  • 基金资助:
    中国医学科学院中央级公益性科研院所基本科研业务费专项(2018PT32003);中国医学科学院中央级公益性科研院所基本科研业务费专项(2017PT32004)

Correlation between CT Texture Analysis and Synchronous Distant Metastasis in Patients with Lymph Node-negative Colorectal Cancer

FANG Yue,WANG Guorong,WANG Zhiwei(),JIN Zhengyu   

  1. Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2019-09-09 Online:2020-12-30 Published:2021-01-11
  • Contact: WANG Zhiwei E-mail:zhiweiwang1981@sina.com
  • Supported by:
    Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2018PT32003);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2017PT32004)

摘要:

目的 探讨CT纹理指标与淋巴结阴性的结直肠癌患者同时性远处转移的相关性。方法 回顾性分析82例淋巴结阴性结直肠癌患者的术前CT图像,12例患者伴同时性远处转移,70例不伴同时性远处转移,使用TexRAD软件对平扫及门脉期CT图像上病灶的最大层面进行分析,空间缩放因子(SSF)取0和2~6时获得6个纹理参数,比较两组之间各纹理参数值的差异性,计数资料使用卡方检验进行分析,计量资料使用曼-惠特尼检验进行分析。结果 同时性远处转移组和无同时性转移组间CT平扫图像上,SSF=3时的偏度值差异有统计学意义(P=0.031);CT增强图像上,SSF=2、3、5、6时的熵值差异有统计学意义(P分别为0.048、0.027、0.016、0.017),SSF=2的峰度值差异有统计学意义(P=0.026)。综合分析这6组有组间差异的纹理指标,当界值取0.636时,诊断同时性远处转移的敏感性为75%、特异性为89%。结论 CT纹理分析技术与淋巴结阴性结直肠癌患者伴同时性远处转移的诊断具有一定相关性。

关键词: 结直肠癌, 淋巴结阴性, 同时性远处转移, CT纹理分析

Abstract:

Objective To investigate the correlation between CT texture analysis and synchronous distant metastasis in patients with lymph node-negative colorectal cancer. Methods The preoperative CT images of 82 patients with lymph node-negative colorectal cancer were analyzed retrospectively.There were 12 patients with simultaneous distant metastasis and 70 patients without simultaneous distant metastasis.The maximum plane of the lesion on plain scan and portal CT images was analyzed by TexRAD software.When the spatial scaling factor(SSF)was 0 and 2-6,six texture parameters were obtained,and the differences of texture parameters between the two groups were compared.The counting data were analyzed by chi-square test and the measurement data by Mann-Whitney test. Results There was a significant difference in the skewness of SSF=3 between the simultaneous distant metastasis group and the non-synchronous metastasis group on plain CT scan(P=0.031).On contrast-enhanced CT images,the entropy values of SSF=2,3,5,and 6 were statistically significant(P=0.048,P=0.027,P=0.016,P=0.017),and the peak values of SSF=2 were statistically significant(P=0.026).According to the comprehensive analysis of the texture parameters of the six groups,when the boundary value was 0.636,the sensitivity and specificity for the diagnosis of simultaneous distant metastasis were 75% and 89%,respectively. Conclusion CT texture analysis is useful in the diagnosis of synchronous distant metastasis in patients with lymph node-negative colorectal cancer.

Key words: colorectal cancer, lymph node negative, simultaneous distant metastasis, CT texture analysis

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