Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (4): 568-572.doi: 10.3881/j.issn.1000-503X.10002

• Review Articles • Previous Articles     Next Articles

Relationship between Autophagy and Curcumin-induced Anticancer Effect

XU Jiming, DING Haoran, LI Zhixin, WANG Hongjun()   

  1. Department of Histology and Embryology,Jilin Medical University,Jilin 132013,China
  • Received:2017-08-31 Online:2018-08-30 Published:2018-09-08
  • Supported by:
    Supported by the Natural Sciences Foundation of Jilin Provincial Science and Technology Department(20130101140JC) and Jilin Provincial Training Program of Innovation and Entrepreneurship for Undergraduates(2015)

Abstract:

Curcumin is a polyphenol extracted from turmeric rhizome and has multiple pharmacological roles. Recently,its anticancer properties have been recognized. Also,curcumin regulates autophagy in tumor cells via signaling pathways including AMP-activated protein kinase,mammalian target of rapamycin,transcription factor EB,Beclin-1,B-cell lymphoma 2,and endoplasmic reticulum stress. Considering the complicated crosstalk between autophagy and apoptosis,in this article we summaize the mechanism of curcumin-induced autophagy and its effect on apoptosis,with an attempt to provide insights on tumor therapy.

Key words: curcumin, autophagy, cell apoptosis

CLC Number: