Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (4): 510-518.doi: 10.3881/j.issn.1000-503X.10081

• Original Articles • Previous Articles     Next Articles

Associations of the MicroRNA-143/145 Polymorphisms with Cardiovascular Risk Factors and the Severity of Coronary Heart Disease

CHEN Yun1, LUO Zhi1, ZENG Wei1, LAI Feiya2, CHEN Qiuhong2, Lü Zhan1(), SONG Yongyan3()   

  1. 1 Department of Cardiology,Affiliated Hospital,College of Preclinical Medicine,North Sichuan Medical College,Nanchong,Sichuan 637000,China
    2 School of Clinical Medicine,College of Preclinical Medicine,North Sichuan Medical College,Nanchong,Sichuan 637000,China
    3 Department of Biochemistry,College of Preclinical Medicine,North Sichuan Medical College,Nanchong,Sichuan 637000,China
  • Received:2017-10-09 Online:2018-08-30 Published:2018-09-08
  • Supported by:
    Supported by the Key Project of Education Department of Sichuan Province(17ZA0172) and the Cooperative Project on Scientific Research between Nanchong City and North Sichuan Medical College(NSMC20170403)

Abstract:

Objective To explore the possible effects of the microRNA(miR)-143/145 polymorphisms on cardiovascular risk factors and the severity of coronary heart disease(CHD) in Chinese Han people. Methods Polymerase chain reaction-restriction fragment length polymorphism analysis was employed to identify the genotypes of the rs353292 and rs4705343 polymorphisms for 380 patients with CHD and 163 CHD-free controls. The physiological and biochemical parameters between the genotypes were compared in the CHD patients and in controls,and the incidence of myocardial infarction(MI) was also compared between the genotypes in the CHD patients. Results The subjects with the rs353292 TT genotype had higher serum levels of triglycerides(F=3.00,P=0.05) and glucose(F=9.91,P<0.001) than the C carriers,and the subjects with the rs4705343 TT genotype had significantly higher prevalence of hypertension(χ2=6.35,P=0.04) than the C carriers in the control group. The patients with the rs353292 TT genotype had significantly higher serum levels of hypersensitive C-reactive protein(hs-CRP)(F=8.43,P<0.001) than the C carriers in the CHD group,and the frequency of MI was significantly higher in the patients with the rs353292 TT genotype than that in the C carrier patients(χ2=5.29,P=0.02). Conclusion The T allele of the rs353292 polymorphism is associated with serum hs-CRP levels in CHD patients,and it may affect the occurrence and development of MI by up-regulation of CRP gene through miR-143/145. The rs4705343 polymorphism is not related to the risk and severity of CHD.

Key words: miR-143/145, rs353292, rs4705343, coronary heart disease, hypersensitive C-reactive protein

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