Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (5): 699-704.doi: 10.3881/j.issn.1000-503X.10086

• Review Articles • Previous Articles     Next Articles

Research Advances in Hypothalamic-pituitary Dysfunction Related to Traumatic Brain Injury

LIU Yang1, YAO Yong1, ZHU Huijuan2()   

  1. 1 Department of Neurosurgery, Health and Family Planning Commission,Department of Endocrinology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2 Key Laboratory of Endocrinology of National, Health and Family Planning Commission,Department of Endocrinology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
  • Received:2017-10-09 Online:2018-10-30 Published:2018-11-07
  • Contact: Huijuan ZHU E-mail:shengxin2004@163.com
  • Supported by:
    Supported by the National Key Program of Clinical Science(WBYZ2011-873)

Abstract:

Traumatic brain injury(TBI)is a major cause of hypothalamopituitary dysfunction. TBI-related hypothalamopituitary dysfunction is more common in the acute phase. Disturbance of pituitary/gonadal axis and growth hormone axis,as well as posterior pituitary dysfunction including central diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion,are the most frequently seen. During the chronic phase of TBI,anterior hypopituitarism is the major concern,which affects the quality of life. Risk factors for hypothalamopituitary dysfunction following TBI include low Glasgow score,high body mass index,hypoxia,older age,longer intensive care unit stay and longer coma status,radiological evidence of acute brain injury,and increased intracranial pressure. Children and adolescents are in a crucial period of growth and development,and therefore TBI-related pituitary dysfunction during this period can substantially affect the cognition and behaviors. There is currently no reliable biochemical marker predicting hypothalamopituitary dysfunctions. Therefore,it is of great importance to evaluate the pituitary function and take appropriate hormone replacement for moderate-severe TBI patients or mild TBI patients with apparent symptoms,especially for patients with water-electrolyte disturbance and adrenal deficiency. Growth hormone and gonadal hormone replacement therapies are crucial for children and adolescents.

Key words: traumatic brain injury, pituitary dysfunction, adolescent, hormone replacement, monitoring and treatment

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