Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (5): 705-709.doi: 10.3881/j.issn.1000-503X.10123

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Evaluation of Uterine Tumor Angiogenesis with Quantitative Magnetic Resonance Imaging Perfusion Parameters

XU Aqiao1, ZHAO Zhenhua2(), YANG Jianfeng2, WEI Mingzhu2, ZHENG Jing1, LU Junmin1, HU Hongjie3, ZHANG Shengjian4   

  1. 1 Department of Radiology,Shaoxing Central Hospital,Shaoxing,Zhejiang 312030,China
    2 Department of Radiology,Shaoxing People’s Hospital,Shaoxing,Zhejiang 312000,China;
    3 Department of Radiology,Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang,University,Hangzhou 310000,China
    4 Department of Radiology,Tumor Hospital Affiliated to Fudan University,Shanghai 200032,China;
  • Received:2017-10-23 Online:2018-10-30 Published:2018-11-07
  • Contact: Zhenhua ZHAO
  • Supported by:
    the Zhejiang General Medical and Health Research Project(2014KYA215);the Zhejiang General Medical and Health Research Project(2015RCA024);the Zhejiang General Medical and Health Research Project(2015KYB402)


The development and metastasis of uterine tumors depend highly on tumor angiogenesis. Multiphase dynamic contrast-enhanced magnetic resonance imaging can quantitatively describe the hemodynamic changes of uterine tumors based on a variety of tracer kinetic models and time-signal curves and by simulating the distribution of contrast inside and outside the blood vessels. Functional parameters can accurately and noninvasively assess tumor angiogenesis. It provides a non-invasive functional evaluation method for the differential diagnosis,staging,response evaluation,and prognostic prediction of uterine tumors.

Key words: magnetic resonance imaging, uterine tumor, microvascular density, vascular endothelial growth factor

CLC Number: