Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (6): 822-826.doi: 10.3881/j.issn.1000-503X.10246

• Review Articles • Previous Articles     Next Articles

Role of Hepatocyte Growth Factor in Wound Repair

LIN Xiaoying,WANG Hong(),TAN Yuan   

  1. Department of Burns,the Second Affiliated Hospital,Kunming Medical University, Burn Institute of Yunnan Province,Kunming 650101,China
  • Received:2017-12-21 Online:2018-12-20 Published:2019-01-03
  • Supported by:
    Supported by Regional Sciences Foundation of the National Natural Sciences Foundation of China(81660321)


Hepatocyte growth factor (HGF) is a multifunctional cytokine that is related to many diseases. HGF mainly contributes to cell migration,proliferation,and survival and regulates vascular angiogenesis,matrix deposition,and degradation of wound healing. HGF also promotes wound reepithelialization and reduces scar formation. This review article summarizes the role of HGF in wound repair and the relationship between HGF and other growth factors,especially when applied for the clinical treatment of chronic skin ulcers.

Key words: hepatocyte growth factor, wound repair, diabetes mellitus

CLC Number: