Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (6): 827-831.doi: 10.3881/j.issn.1000-503X.10273

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Long Non-coding RNA Act as Regulators of Autophagy in Disease Treatment

GONG Ge1,YIN Jian2,YANG Xiang1,ZHANG Xinghu1,ZHANG Yuan1,WAN Wenhui1()   

  1. 1Department of Geriatrics,Nanjing General Hospital of PLA,Nanjing 210002,China
    2Department of Orthopaedics,the Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing 211100,China
  • Received:2018-01-05 Online:2018-12-20 Published:2019-01-03
  • Supported by:
    Supported by Special Fund for Military Health(13BJZ11);Supported by Special Fund for Military Health(17BJZ17);the Hospital Project of the Nanjing General Hospital of PLA(2017065)


Long non-coding RNA (lncRNA) refer to transcripts longer than 200 nucleotides that have a low coding potential. Autophagy,a unique life phenomenon of eukaryotic cells,removes excess or damaged organelles during cell growth and development and plays a key role in maintaining homeostasis. As a key regulator of cellular metabolism,lncRNA are involved in disease treatment by regulating autophagy. This article summarizes the role of lncRNA in the treatment of cancer,cardiovascular and cerebrovascular diseases,neurodegenerative diseases,and bacterial infections and analyzes the molecular mechanisms of lncRNA in regulating autophagy,along with prospects of its applications in other areas.

Key words: long non-coding RNA, autophagy, disease treatment

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