Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (1): 63-67.doi: 10.3881/j.issn.1000-503X.10517
• Original Articles • Previous Articles Next Articles
GU Junjie,SUN Zhao,ZHAO Lin,BAI Chunmei()
Received:
2018-05-03
Online:
2019-02-28
Published:
2019-03-06
Contact:
Chunmei BAI
E-mail:baichunmei1964@163.com
Supported by:
CLC Number:
GU Junjie,SUN Zhao,ZHAO Lin,BAI Chunmei. Expression of α-smooth Muscle Actin in Advanced Colorectal Cancer Tissue and Its Significance in Chemotherapy Response Prediction and Prognosis[J].Acta Academiae Medicinae Sinica, 2019, 41(1): 63-67.
Table 1
Relationship between α-SMA expression and clinicopathological characteristics and chemotherapy response in 52 patients with advanced colorectal cancer"
特征Characteristics | n | α-SMA表达α-SMA expression | χ2 | P | |
---|---|---|---|---|---|
低表达Low expression | 高表达High expression | ||||
性别Gender | 0.515 | 0.332 | |||
男Male | 30 | 12 | 18 | ||
女Female | 22 | 11 | 11 | ||
年龄(岁)Age(years) | 0.113 | 0.730 | |||
<60 | 19 | 9 | 10 | ||
≥60 | 33 | 14 | 19 | ||
组织分化程度Tissue differentiation | 1.852 | 0.604 | |||
高分化Highly differentiated | 5 | 1 | 4 | ||
中分化Moderately differentiated | 37 | 17 | 20 | ||
低分化Poorly differentiated | 7 | 4 | 3 | ||
未分化Undifferentiated | 3 | 1 | 2 | ||
肿瘤部位Tumor location | 3.675 | 0.159 | |||
左半结肠癌Left colonic carcinoma | 40 | 15 | 25 | ||
右半结肠癌Right colonic carcinoma | 11 | 7 | 4 | ||
左右半结肠癌Left and right colonic carcinoma | 1 | 1 | 0 | ||
化疗疗效Chemotherapy response | 14.470 | 0.000 | |||
化疗敏感Responders | 30 | 20 | 10 | ||
化疗耐药 Non-responders | 22 | 3 | 19 |
[1] |
Wanqing C, Kexin S, Rongshou Z , et al. Cancer incidence and mortality in China,2014[J]. Chin J Cancer Res, 2018,30(1):1-12.
doi: 10.21147/j.issn.1000-9604.2018.01.01 pmid: 29545714 |
[2] |
Erez N, Glanz S, Raz Y , et al. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors[J]. Biochem Biophys Res Commun, 2013,437(3):397-402. DOI: 10.1016/j.bbrc.2013.06.089.
doi: 10.1016/j.bbrc.2013.06.089 pmid: 23831470 |
[3] |
Linlin W, Fang Z, Jianying C , et al. CAFs enhance paclitaxel resistance by inducing EMT through the IL-6/JAK2/STAT3 pathway[J]. Oncology Reports, 2018,39(5):2081-2090. DOI: 10.3892/or.2018.6311.
doi: 10.3892/or.2018.6311 pmid: 29565447 |
[4] |
De Wever O, Mareel M . Role of myofibroblasts at the invasion front[J]. Biol Chem, 2002,383(1):55-67.DOI: 10.1515/BC.2002.006.
doi: 10.1515/BC.2002.006 |
[5] |
Polanska UM, Orimo A . Carcinoma associated fibroblasts:non-neoplastic tumour-promoting mesenchymal cells[J]. Cell Physiol, 2013,228(8):1651-1657.DOI: 10.1002/jcp.24347.
doi: 10.1002/jcp.24347 pmid: 23460038 |
[6] |
Huynh PT, Beswick EJ, Coronado YA , et al. CD90+stromal cells are the major source of IL-6,which supports cancer stem-like cells and inflammation in colorectal cancer[J]. Int J Cancer, 2016,138(8):1971-1981. DOI: 10.1002/ijc.29939.
doi: 10.1002/ijc.29939 |
[7] |
Johansson AC, Ansell A, Jerhammar F , et al. Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cells[J]. Mol Cancer Res, 2012,10(9):1158-1168. DOI: 10.1158/1541-7786.MCR-12-0030.
doi: 10.1158/1541-7786.MCR-12-0030 pmid: 22809838 |
[8] |
Samuel GR, Natalia GDM, Mireia BA , et al. Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells[J]. Oncotarget, 2016,7(37):59766-59780. DOI: 10.18632/oncotarget.11121.
doi: 10.18632/oncotarget.11121 pmid: 27517495 |
[9] |
Mueller MM, Fusenig NE . Friends or foes-bipolar effects of the tumour stroma in cancer[J]. Nat Rev Cancer, 2004,4(11):839-849. DOI: 10.1038/nrc1477.
doi: 10.1038/nrc1477 pmid: 15516957 |
[10] |
McAnulty RJ . Fibroblasts and myofibroblasts:their source,function and role in disease[J]. Int J Biochem Cell Biol, 2007,39(4):666-671. DOI: 10.1016/j.biocel.2006.11.005.
doi: 10.1016/j.biocel.2006.11.005 pmid: 17196874 |
[11] | Mesker WE, Junggeburt JM, Szuhai K , et al. The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage[J]. Cell Oncol, 2007,29(5):387-398. |
[12] |
Tsujino T, Seshimo I, Yamamoto H , et al. Stromal myofibroblasts predict disease recurrence for colorectal cancer[J]. Clin Cancer Res, 2007,13(7):2082-2090.DOI: 10.1158/1078-0432.CCR-06-2191.
doi: 10.1158/1078-0432.CCR-06-2191 pmid: 17404090 |
[13] |
Mercedes H, Alberto H, Gemma D , et al. Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients[J]. Cancer Sci, 2013,104(4):437-444. DOI: 10.1111/cas.12096.
doi: 10.1111/cas.12096 pmid: 23298232 |
[14] |
Choi SY, Sung R, Lee SJ , et al. Podoplanin,α-smooth muscle actin or S100A4 expressing cancer-associated fibroblasts are associated with different prognosis in colorectal cancers[J]. J Korean Med Sci, 2013,28(9):1293-1301.DOI: 10.3346/jkms.2013.28.9.1293.
doi: 10.3346/jkms.2013.28.9.1293 pmid: 3763102 |
[1] | LI Ningning,ZHOU Jianfeng,ZHAO Lin,YING Hongyan,JIA Ning. Efficacy and Safety of Apatinib in Treating Advanced Colorectal Cancer [J]. Acta Academiae Medicinae Sinica, 2019, 41(2): 170-174. |
[2] | WU Haiting,LI Hang,YE Wei,CAI Jianfang,WEN Yubing,CHEN Limeng,LI Mingxi,LI Xuemei. Effect of Glucocorticoid Pulse Therapy on Short-term Prognosis of Anti-neutrophil Cytoplasmic Antibodies-associated Glomerulonephritis [J]. Acta Academiae Medicinae Sinica, 2019, 41(1): 68-74. |
[3] | YU Junhui,LI Xinbao,WANG Dong,YAO Hongwei,JIN Lan,YANG Yingchi,LI Yan. Feasibility and Safety of Enhanced Recovery after Surgery for Elderly Patients with Colorectal Cancer [J]. Acta Academiae Medicinae Sinica, 2018, 40(6): 730-735. |
[4] | CUI Ge,FENG Wenming,ZHANG Ting,ZHU Guoliang,SHI Qilin,ZHANG Xiaolan,XIA Hui. Validation and Evaluation of Diagnostic Efficiency of Genes Associated with Colorectal Cancer with Hyperglycemia [J]. Acta Academiae Medicinae Sinica, 2018, 40(6): 769-777. |
[5] | WU Xi,DENG Bingbin,BAI Chunmei,ZHAO Lin,CHENG Yuejuan,LI Xiaoyuan,LI Ningning,ZHOU Jianfeng. Efficacy and Prognostic Factors of Cetuximab Therapy in Treating KRAS or All RAS Wild-type Metastatic Colorectal Cancer [J]. Acta Academiae Medicinae Sinica, 2018, 40(5): 660-666. |
[6] | LI Ningning, BAI Chunmei, WANG Yingyi, GE Yuping, ZHAO Lin. Clinical Analysis of 25 Cases of Malignant Peritoneal Mesothelioma [J]. Acta Academiae Medicinae Sinica, 2018, 40(2): 211-218. |
[7] | Jianjun WANG, Xiaomin LI, Lei HE, Shuzhi ZHONG, Yanxiao PENG, Na JI. Expression and Function of Long Non-coding RNA CASC19 in Colorectal Cancer [J]. Acta Academiae Medicinae Sinica, 2017, 39(6): 756-761. |
[8] | Heng LI, Wenjie XIONG, Huimin LIU, Shuhua YI, Rui Lü, Tingyu WANG, Zhen YU, Lugui QIU, Zengjun LI. Efficacy of Rituximab for Patients with Chronic Lymphocytic Leukemia [J]. Acta Academiae Medicinae Sinica, 2017, 39(6): 800-805. |
[9] | Yong XIE, Wenjing LIU, Yuewu LIU, Wenze WANG, Mengyi WANG, Hongfeng LIU, Xiaoyi LI, Weisheng GAO. Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma [J]. Acta Academiae Medicinae Sinica, 2017, 39(3): 377-382. |
[10] | Kan WANG, Yiqing YIN. Risk Factors and Prognosis of Reintubation Following Surgeries under General Anesthesia [J]. Acta Academiae Medicinae Sinica, 2017, 39(1): 145-149. |
[11] | Xue-liang WU, Jun XUE, Li-kun WANG, Dong-dong YANG, Ming QU, Fei GUO, Guang-yuan SUN, Lei HAN, Rui-min YANG. Expressions of Inhibitors of DNA Binding-1 and Matrix Metalloproteinase-9 in Colorectal Adenocarcinoma Tissues and Their Correlations with Microvessel Density [J]. Acta Academiae Medicinae Sinica, 2016, 38(6): 696-701. |
[12] | Hui-min WANG, Ming-zi TAN, Song ZHANG, Xiao LI, Jian GAO, Dan-ye ZHANG, Ying-ying HAO, Song GAO, Juan-juan LIU, Bei LIN. Expressions of CD44,CD47,and c-met in Ovarian Clear Cell Carcinoma and Their Clinical Significance [J]. Acta Academiae Medicinae Sinica, 2016, 38(6): 720-725. |
[13] | Min-er ZHONG, Lai XU, Qiong XU, Wu-yang JI, Bei-zhan NIU, Hui-zhong QIU, Bin WU. Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage Ⅲ Colorectal Cancer [J]. Acta Academiae Medicinae Sinica, 2016, 38(3): 294-299. |
[14] | Jing ZUO, Yan SONG, Zhuo LI, Ling-ying WU. Relationship between P53 Protein Expression and Prognosis of Advanced Ovarian Serous Adenocarcinoma [J]. Acta Academiae Medicinae Sinica, 2016, 38(2): 169-174. |
[15] | Hao LI, Xi-tao WANG, Ai-qun ZHANG, Xiang-fei MENG, Qiang YU, Wen-ping LÜ, Wei-dong DUAN, Jia-hong DONG. Comparison of the Predictive Values of Eight Staging Systems for Primary Liver Cancer in Prognosis of Combined Hepatocellular-cholangiocellular Carcinoma Patients after Surgery [J]. Acta Academiae Medicinae Sinica, 2016, 38(2): 175-181. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||
|