Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (6): 778-784.doi: 10.3881/j.issn.1000-503X.10520

• Original Articles • Previous Articles     Next Articles

Distribution of Telocytes in Vital Organs of ApoE -/- Mice

XU Ying1,TIAN Hu1(),YU Jian1,CHENG Jialin2,ZHAO Yucheng2   

  1. 1Department of General Surgery,Shandong University Affiliated Shandong Provincial Qianfoshan Hospital,Jinan 250014,China
    2Graduate School of Tai Shan Medical College,Tai’an,Shandong 271000,China;
  • Received:2018-05-04 Online:2018-12-20 Published:2019-01-03
  • Supported by:
    Supported by the Critical Research Subject of Shandong(2016GGB14221)


Objective To identify and verify the distribution of Telocytes derived from heterogeneous interstitial cells in the vital organs of ApoE -/- mice.
Methods Heart,kidney,and liver tissues were harvested from ApoE -/- adult mice. Immunohistochemical assays were performed by using different immunobiological markers.
Results Telocytes were found in these vital organs. The expressions of immunobiological markers differed among different organs. CD34,CD117,and CD28 were positively expressed in Telocytes in cardiac tissue;CD117 and plateled-derived growth factor-α were negatively expressed in Telocytes in renal tissue;and CD117 and plateled-derived growth factor receptor-α had negative expression in Telocytes in hepatic tissue. Furthermore,the distribution of Telocytes also differed in the same organ.
Conclusions Telocytes exist in the vital organs of ApoE -/- mice,as demonstrated by immunohistochemisty assay. The expressions of immunobiological markers differ among Telocytes in different organs.

Key words: ApoE -/- mice, Telocytes, CD34, CD117, plateled-derived growth factor receptor-α

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