Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (5): 597-602.doi: 10.3881/j.issn.1000-503X.10524

• Comprehensive Treatment of Reducing Weight Forum • Previous Articles     Next Articles

Nonalcoholic Fatty Liver Disease and Weight Loss

PING Fan, LI Yuxiu()   

  1. Key Laboratory of Endocrinology of Ministry of Health,Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2018-05-07 Online:2018-10-30 Published:2018-11-07
  • Contact: Yuxiu LI


Nonalcoholic fatty liver disease(NAFLD)refers to hepatic steatosis without other known causes such as alcohol abuse or hepatic virus infection. NAFLD has become a chronic disease worldwide,and its prevalence is constantly growing. Hepatic insulin resistance caused by obesity results in the deposition of triglycerides in the liver,promoting the occurrence and development of NAFLD. Weight loss is the only safe and effective method for NAFLD. Lifestyle intervention plays a cornerstone role in treating NAFLD;however,most patients can not achieve and maintain the ideal body weight by lifestyle intervention alone. Glucagon-like peptide-1 receptor agonist and metabolic surgery are promising treatments for NAFLD.

Key words: obesity, nonalcoholic fatty liver disease, glucagon-like peptide-1 receptor agonist, metabolic surgery

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