Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (2): 220-227.doi: 10.3881/j.issn.1000-503X.10613
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GUO Ying1,MA Dong1,JIA Shifeng2,LIU Jia1,FAN Shaobei1,ZHANG Meng1,SHI Linran1,JIANG Lili1,SHI Juexin1,WANG Haiqiu3,ZHENG Huanyu3,LI Ou3()
Received:
2018-06-08
Online:
2019-04-28
Published:
2019-05-07
Contact:
Ou LI
E-mail:tsliou@163.com
Supported by:
CLC Number:
GUO Ying,MA Dong,JIA Shifeng,LIU Jia,FAN Shaobei,ZHANG Meng,SHI Linran,JIANG Lili,SHI Juexin,WANG Haiqiu,ZHENG Huanyu,LI Ou. Proliferation of MicroRNA-365 and E74-like Factor 4 in Cervical Cancer Cells and Its Clinical Significance[J].Acta Academiae Medicinae Sinica, 2019, 41(2): 220-227.
Fig 1
Expression of miR-365 in human cervical cancer Normal:normal cervical tissue;SCC:squamous cell carcinoma of the cervix;at=3.802,aP=0.001;bt=28.579,bP=0.001,ct=8.351,cP=0.013,dt=6.435,dP=0.026 compared with HcerEpic cell A.expressions of miR-365 in normal cervical tissue and SCC were detected by real-time fluorescence quantification polymerase chain reaction;B.expressions of miR-365 in three cervical cancer cells(C33A,HeLa,SiHa)and normal control cervical cell HcerEpic were detected by real-time fluorescence quantification polymerase chain reaction"
Table 1
Correlation between miR-365 expression and clinicopathological features of squamous cell carcinoma of the cervix tissues"
临床病理特征 Clinicopathological features | 低表达Low expression | 高表达High expression | t/χ2 | P |
---|---|---|---|---|
年龄( | 53.17±4.11 | 50.47±4.52 | 0.929 | 0.363 |
肿瘤大小Tumor size[n(%)] | 4.891 | 0.027 | ||
≤4cm | 40(30.8) | 9(69.2) | ||
>4cm | 14(70.0) | 6(30.0) | ||
病理分级Pathological grade[n(%)] | 6.906 | 0.009 | ||
高、中分化Well and moderately-differentiated | 16(69.6) | 7(30.4) | ||
低分化Poorly-differentiated | 2(20.0) | 8(80.0) | ||
临床分期Clinical stage[n(%)] | 6.639 | 0.010 | ||
Ⅰ期ⅠStage | 15(71.4) | 6(28.6) | ||
Ⅱ期ⅡStage | 3(25.0) | 9(75.0) |
Table 2
Correlation between ELF4 mRNA expression and clinicopathological features of squamous cell carcinoma of the cervix tissue"
临床病理特征 Clinicopathological features | 低表达Low expression | 高表达High expression | t/χ2 | P |
---|---|---|---|---|
年龄( | 53.85±4.39 | 50.70±4.12 | 1.655 | 0.120 |
肿瘤大小Tumor size[n(%)] | 7.998 | 0.005 | ||
≤4cm | 9(69.3) | 4(30.8) | ||
>4cm | 4(20.0) | 16(80.0) | ||
病理分级Pathological grade[n(%)] | 5.192 | 0.023 | ||
高、中分化Well and moderately-differentiated | 12(52.2) | 11(47.8) | ||
低分化Poorly-differentiated | 1(10.0) | 9(90.0) | ||
临床分期Clinical stage[n(%)] | 4.080 | 0.043 | ||
Ⅰ期ⅠStage | 11(52.4) | 10(47.6) | ||
Ⅱ期ⅡStage | 2(16.7) | 10(83.3) |
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