Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (4): 457-463.doi: 10.3881/j.issn.1000-503X.10637

• Original Articles • Previous Articles     Next Articles

Meta Analysis of Risks of Cardiocerebral Vascular Events in Patients with Primary Biliary Cholangitis

XIE Xi1,TANG Sheng2,WANG Jia1,CHEN Jinwei1,TIAN Jing1,MAO Ni1,LIU Yiming1,LI Fen1()   

  1. 1 Department of Rheumatology,the Second Xiangya Hospital of Central South University,Changsha 410011,China
    2 Department of Internal Medicine,Yongzhou Hospital of Traditional Chinese Medicine,Yongzhou,Hunan 425000,China
  • Received:2018-06-16 Online:2019-08-30 Published:2019-09-05
  • Contact: Fen LI E-mail:lifen0731@csu.edu.cn
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81571599);Supported by the National Natural Sciences Foundation of China(81601435);Hunan Provincial Natural Sciences Foundation of China(2017JJ3450)

Abstract:

Objective To systematically evaluate the risks of cardiocerebral vascular events in patients with primary biliary cholangitis(PBC). Methods We carried out a Meta analysis by RevMan 5.3 software to investigate literatureon the risk of cardiocerebral vascular events in patients with PBC and controls. Results Compared with non-PBC controls,PBC patients had significantly higher risk of coronary events(RR=1.56,P=0.0002);however,the risk of cerebrovascular events showed no significant difference between these two groups(RR=1.01,P=0.94).Subgroup analysis demonstrated a significantly lower risk of transient ischemic attack or carotid stenosis in PBC patients(RR=0.63,P=0.03);however,there was no significant difference in the risk of stroke(RR=1.11,P=0.40). Conclusion Patients with PBC have an increased risk of coronary events but may have a lower risk of transient ischemic attack or carotid stenosis.

Key words: primary biliary cholangitis, coronary heart disease, cerebrovascular event, Meta analysis

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