Acta Academiae Medicinae Sinica
Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (6): 757-764.doi: 10.3881/j.issn.1000-503X.10693
• Original Articles • Previous Articles Next Articles
ZHANG Shu1,2,WANG Ling1,2,WANG Tong1,2,XING Haiqun1,2,HUO Li1,2,LI Fang1,2(
)
Received:2018-07-11
Online:2018-12-20
Published:2019-01-03
Supported by:CLC Number:
ZHANG Shu,WANG Ling,WANG Tong,XING Haiqun,HUO Li,LI Fang. Value of 68Ga-DOTA-TATE Positron Emission Tomography/Computed Tomography in the Localization of Culprit Tumors Causing Osteomalacia with Negative 99mTc-HYNIC-TOC Single Photo Emission Computed Tomography[J].Acta Academiae Medicinae Sinica, 2018, 40(6): 757-764.
Fig 1
A 40-year-old male patient was diagnosed with TIO, 68Ga-DOTA-TATE PET/CT detected the PMT located in the inferior alveolar bone,which was miss-diagnosed by 99mTc-HYNIC-TOC SPECT TIO:tumor-induced osteomalacia;PET/CT:positron emission tomography/computered tomography;SPECT:single photo emission computered tomography;PMT:phosphaturic mesenchymal tumor;SUVmax:maximum standardized uptake value;SUVmean:mean standardized uptake value A. 99mTc-HYNIC-TOC SPECT showed normal result,which was false negative;B. the 68Ga-DOTA-TATE PET maximal intensity projection image showed a small focus of elevated activity in the lower jaw(arrow);C. intense uptake of 68Ga-DOTA-TATE PET was observed (arrow),with the SUVmax and the SUVmean up to 2.97 and 1.75 on the axial PET image;D. the axial PET/CT fusion image showed the lesion was located in the inferior alveolar bone (arrow);E. osteolytic change was observed in the inferior alveolar bone (arrow) on the axial CT image"
Fig 2
A 17-year-old female TIO patient, 68Ga-DOTA-TATE PET/CT detected the culprit tumor located in the distal femur,which was pathologically confirmed as PMT A. the axial PET image of 68Ga-DOTA-TATE showed an intense activity in the lower extremity (arrow),with the SUVmax and SUVmean up to 3.8 and 3.0;B. the PET/CT fusion image showed the lesion was located in the distal femur (arrow);C. the lesion presented accentric osteolytic change with soft-tissue density on corresponding CT image (arrow)"
Fig 3
A 49-year-old male TIO patient, 68Ga-DOTA-TATE PET/CT detected the culprit tumor located in the right femur head,which was negative on 99mTc-HYNIC-TOC SPECT,the lesion was pathologically confirmed as PMT after total hip replacement A. 99mTc-HYNIC-TOC SPECT showed normal result,which was false negative;B. 68Ga-DOTA-TATE PET maximum intensity projection image showed a small focus of increased activity in the right lower extremity(arrow);C. the axial PET image showed an increased activity (arrow)with the SUVmax and SUVmean up to 6.95 and 4.17;D. the PET/CT fusion image showed the lesion was located in the right femur head(arrow);E. corresponding CT image revealed an nodular osteosclerotic change(arrow)"
Fig 4
A 48-year-old female TIO patient, 68Ga-DOTA-TATE PET/CT detected the culprit tumor located in the subcutaneous region of chest wall,which was negative on 99mTc-HYNIC-TOC SPECT,the lesion was confirmed as PMT after surgical resection A. 99mTc-HYNIC-TOC SPECT showed normal result,without no elevated activity;B. 68Ga-DOTA-TATE PET maximum intensity projection image showed normal result,without no elevated activity;C. the axial PET showed an intense activity in the anterior chest wall (arrow),with the SUVmax and SUVmean up to 3.8 and 3.0;D. the PET/CT fusion image showed that the lesion was in the subcutaneous region of chest wall(arrow);E. corresponding CT image revealed a well-circumscribed isodense nodule (arrow)"
Fig 5
A 24-year-old female TIO patient,68Ga-DOTA-TATE PET/CT detected the PMT located in the pleura,which was miss-diagnosed by SPECT A. 99mTc-HYNIC-TOC SPECT showed normal result,which was false-negative;B. 68Ga-DOTA-TATE PET maximum intensity projection image showed an elevated activity in the chest (arrow);C. the axial PET showed the lesion was in the chest wall(arrow),with the SUVmax and SUVmean up to 10.4 and 5.6;D. the PET/CT fusion image showed the lesion was in the pleura (arrow);E. nodular thickening of pleura was observed on corresponding CT image,with spot calcification in it(arrow)"
| [1] |
Hesse E, Moessinger E, Rosenthal H , et al. Oncogenic osteomalacia:exact tumor localization by co-registration of positron emission and computed tomography[J]. J Bone Miner Res, 2007,22(1):158-162. DOI: 10.1359/jbmr.060909.
doi: 10.1359/jbmr.060909 |
| [2] |
Seufert J, Ebert K, Muller J , et al. Octreotide therapy for tumor-induced osteomalacia[J]. N Engl J Med, 2001,345(26):1883-1888. DOI: 10.1056/NEJMoa.010839.
doi: 10.1056/NEJMoa.010839 pmid: 11756579 |
| [3] |
Jing H, Li F, Zhuang H , et al. Effective detection of the tumors causing osteomalacia using [Tc-99m]-HYNIC-octreotide (99mTc-HYNIC-TOC) whole body scan[J]. Eur J Radiol, 2013,82(11):2028-2034. DOI: 10.1016/j.ejrad.2013.04.006.
doi: 10.1016/j.ejrad.2013.04.006 pmid: 23721625 |
| [4] |
Zhang J, Zhu Z, Zhong D , et al. 68Ga DOTATATE PET/CT is an accurate imaging modality in the detection of culprit tumors causing osteomalacia[J]. Clin Nucl Med, 2015,40(8):642-646. DOI: 10.1097/RLU.0000000000000854.
doi: 10.1097/RLU.0000000000000854 pmid: 26053726 |
| [5] |
Feng J, Jiang Y, Wang O , et al. The diagnostic dilemma of tumor induced osteomalacia:a retrospective analysis of 144 cases[J]. Endocr J, 2017,64(7):675-683. DOI: 10.1507/endocrj.EJ16-0587.
doi: 10.1507/endocrj.EJ16-0587 pmid: 28450684 |
| [6] |
Jiang Y, Xia WB, Xing XP , et al. Tumor-induced osteomalacia:an important cause of adult-onset hypophosphatemic osteomalacia in China:report of 39 cases and review of the literature[J]. J Bone Miner Res, 2012,27(9):1967-1975. DOI: 10.1002/jbmr.1642.
doi: 10.1002/jbmr.1642 pmid: 22532501 |
| [7] |
Mak MP, da Costa e Silva VT, Martin RM , et al. Advanced prostate cancer as a cause of oncogenic osteomalacia:an underdiagnosed condition[J]. Support Care Cancer, 2012,20(9):2195-2197. DOI: 10.1007/s00520-012-1474-z.
doi: 10.1007/s00520-012-1474-z pmid: 22552356 |
| [8] |
Elderman JH, Wabbijn M,de Jongh F ,et al. Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin’s lymphoma[J]. BMJ Case Rep, 2016,2016. DOI: 10.1136/bcr-2015-213954.
doi: 10.1136/bcr-2015-213954 pmid: 27118742 |
| [9] |
Harish S, Jurriaans E, Jan E , et al. Giant cell tumour of soft tissue causing oncogenic osteomalacia:report demonstrating the use of octreotide scintigraphy in tumour localization[J]. Clin Radiol, 2008,63(1):101-107. DOI: 10.1016/j.crad.2007.05.017.
doi: 10.1016/j.crad.2007.05.017 pmid: 18068797 |
| [10] |
Yamada Y, Kinoshita I, Kenichi K , et al. Histopathological and genetic review of phosphaturic mesenchymal tumours,mixed connective tissue variant[J]. Histopathology, 2018,72(3):460-471. DOI: 10.1111/his.13377.
doi: 10.1111/his.13377 pmid: 28858396 |
| [11] |
Reubi JC, Waser B, Laissue JA , et al. Somatostatin and vasoactive intestinal peptide receptors in human mesenchymal tumors:in vitro identification[J]. Cancer Res, 1996,56(8):1922-1931.
doi: 10.1002/(SICI)1097-0142(19960415)77:8+<1752::AID-CNCR27>3.0.CO;2-W pmid: 8620515 |
| [12] |
Chong WH, Andreopoulou P, Chen CC , et al. Tumor localization and biochemical response to cure in tumor-induced osteomalacia[J]. J Bone Miner Res, 2013,28(6):1386-1398. DOI: 10.1002/jbmr.1881.
doi: 10.1002/jbmr.1881 pmid: 23362135 |
| [13] |
Antunes P, Ginj M, Zhang H , et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals ?[J]. Eur J Nucl Med Mol Imaging, 2007,34(7):982-993. DOI: 10.1007/s00259-006-0317-x.
doi: 10.1007/s00259-006-0317-x pmid: 17225119 |
| [14] |
于江媛, 李洁, 李囡 , 等. 胃肠胰神经内分泌肿瘤患者99Tcm-HYNIC-TOC SPECT与68Ga-DOTA-TATE PET/CT显像的对比研究[J]. 中华核医学与分子影像杂志, 2015,35(4):289-292. DOI: 10.3760/cma.j.issn.2095-2848.2015.04.013.
doi: 10.3760/cma.j.issn.2095-2848.2015.04.013 |
| [15] |
Hofman MS, Kong G, Neels OC , et al. High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours[J]. J Med Imaging Radiat Oncol, 2012,56(1):40-47. DOI: 10.1111/j.1754-9485.2011.02327.x.
doi: 10.1111/j.1754-9485.2011.02327.x pmid: 22339744 |
| [16] |
Reubi JC, Schar JC, Waser B , et al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use[J]. Eur J Nucl Med, 2000,27(3):273-282.
doi: 10.1007/s002590050034 pmid: 10774879 |
| [17] |
Satyaraddi A, Cherian KE, Shetty S , et al. Musculoskeletal oncogenic osteomalacia-an experience from a single centre in South India[J]. J Orthop, 2017,14(1):184-188. DOI: 10.1016/j.jor.2016.12.010.
doi: 10.1016/j.jor.2016.12.010 pmid: 28123260 |
| [18] |
徐加利, 余卫, 王华 , 等. 肿瘤源性骨软化症责任肿瘤的CT和MRI表现[J]. 临床放射学杂志, 2017,36(8):1165-1169. DOI: 10.13437/j.cnki.jcr.2017.08.030.
doi: 10.13437/j.cnki.jcr.2017.08.030 |
| [19] |
Higley M, Beckett B, Schmahmann S , et al. Locally aggressive and multifocal phosphaturic mesenchymal tumors:two unusual cases of tumor-induced osteomalacia[J]. Skeletal Radiol, 2015,44(12):1825-1831. DOI: 10.1007/s00256-015-2246-x.
doi: 10.1007/s00256-015-2246-x pmid: 26341245 |
| [20] |
Nakamura K, Ohishi M, Matsunobu T , et al. Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum:a case report[J]. Mod Rheumatol, 2018,28(5):906-910. DOI: 10.3109/14397595.2016.1173322.
doi: 10.3109/14397595.2016.1173322 pmid: 27141918 |
| [21] |
Minisola S, Peacock M, Fukumoto S , et al. Tumour-induced osteomalacia[J]. Nat Rev Dis Primers, 2017,3:17044. DOI: 10.1038/nrdp.2017.44.
doi: 10.1038/nrdp.2017.44 |
| [22] |
Paquet M, Gauthe M, Zhang Yin J , et al. Diagnostic performance and impact on patient management of (68)Ga-DOTA-TOC PET/CT for detecting osteomalacia-associated tumours[J]. Eur J Nucl Med Mol Imaging, 2018,45(10):1710-1720. DOI: 10.1007/s00259-018-3971-x.
doi: 10.1007/s00259-018-3971-x |
| [23] |
Zuo QY, Wang H, Li W , et al. Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors:retrospective review of 12 patients[J]. BMC Musculoskelet Disord, 2017,18(1):403. DOI: 10.1186/s12891-017-1756-1.
doi: 10.1186/s12891-017-1756-1 pmid: 5609032 |
| [1] | HAO Yunxiu,WANG Kefei,WANG Guorong,FANG Yue,WANG Zhiwei,XUE Huadan,JIN Zhengyu. Value of the CT Angiography in Displaying the Anatomical Variations of the Origin of Uterus Artery [J]. Acta Academiae Medicinae Sinica, 2019, 41(2): 216-219. |
| [2] | XU Xiaoli,SONG Wei,SUI Xin,SONG Lan,HUANG Yao,WANG Xiao,JIN Zhengyu. Features and Prospects of Dual-energy Computed Tomography for Evaluation of Lung Cancer [J]. Acta Academiae Medicinae Sinica, 2019, 41(2): 273-277. |
| [3] | LUO Chuncai,TANG Tian,LI Tao,YANG Li,LI Jinfeng,ZHANG Xinghua,ZHANG Jing. Value of CT Angiography Using Low Tube Voltage and Low Contrast Combined with Iterative Model Reconstruction in Patients with Coronary Artery Bypass Grafts [J]. Acta Academiae Medicinae Sinica, 2018, 40(6): 744-749. |
| [4] | YAN Fei, JIN Xin, ZHANG Xinghua, WU Jian. Chest CT Findings of Primary Neuroendocrine Tumor of Thymus:Analysis of 7 Cases [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 468-472. |
| [5] | DANG Haodan, CHEN Yu, SHI Xiaohua, HOU Bo, XING Haiqun, ZHANG Tao, CHEN Xingming, ZHANG Zhuhua, XUE Huadan, JIN Zhengyu. Correlations of 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Parameters with the Pathological Differentiation of Head and Neck Squamous Cell Carcinoma and Their Diagnostic Efficiencies [J]. Acta Academiae Medicinae Sinica, 2018, 40(2): 242-249. |
| [6] | Xiao-li XU, Wei SONG, Xin SUI, Lan SONG, Qian-ni DU, Xiao WANG. Radiological and Clinical Features of Eosinophilic Granulomatosis with Polyangiitis [J]. Acta Academiae Medicinae Sinica, 2016, 38(5): 617-620. |
| [7] | Xiao-li XU, Wei SONG, Xin SUI, Lan SONG, Xiao WANG, Rui-e FENG, Yuan LI. Computed Tomographic and Pathological Features of Primary Pulmonary Sarcomatoid Carcinoma [J]. Acta Academiae Medicinae Sinica, 2016, 38(1): 93-98. |
| [8] | Na NIU, Zhao-hui ZHU, Yan-ru MA, Hai-qun XING, Fang LI. Features of Acquired Immunodeficiency Syndrome-related Lymphoma on 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography [J]. Acta Academiae Medicinae Sinica, 2015, 37(5): 602-606. |
| [9] | Yong-hong DANG, Jiong CAI, Xin LI, Ling WANG, Fang LI. Imaging Potential and Biodistribution in vivo of 2-[18F]Fluoropropionic Acid in Breast Cancer-bearing Mice [J]. Acta Academiae Medicinae Sinica, 2015, 37(3): 320-324. |
| [10] | Fang WU, Zu-long CAI, Shu-ping TIAN, Xin JIN, Rui JING, Yue-qing YANG, Ying-na LI, Shao-hong ZHAO. Correlations between Pathologic Subtypes/Immunohistochemical Implication and CT Characteristics of Lung Adenocarcinoma≤1 cm with Ground-glass Opacity [J]. Acta Academiae Medicinae Sinica, 2015, 37(2): 163-170. |
| [11] | SUN Hao, XUE Hua-dan, JIN Zheng-yu, WANG Xuan, CHEN Yu, HE Yong-lan, ZHANG Da-ming, ZHU Liang, WANG Yun, QI Bing, XU Kai, WANG Ming. Clinical Application of High-pitch Excretory Phase Images during Dual-source CT Urography with Stellar Photon Detector [J]. Acta Academiae Medicinae Sinica, 2014, 36(5): 516-521. |
| [12] | MING Wei-di,LI Xiao-guang,XUE Hua-dan,LIANG Ji-xiang,JIN Zheng-yu. Value of Enhanced Computed Tomography in the Diagnosis of Adrenal Hemangioma [J]. Acta Academiae Medicinae Sinica, 2014, 36(4): 347-350. |
| [13] | WANG Zhi-wei,WANG Yi-ning,KONG Ling-yan,CAO Jian,LI Shuo,ZHOU Kang,JIN Zheng-yu,WU Wei. Value of Dual-source Computed Tomography Angiography of Coronary Artery for Preoperative Evaluation of Old Patients Scheduled for Noncardiac Surgery [J]. Acta Academiae Medicinae Sinica, 2014, 36(4): 363-368. |
| [14] | CHEN Zhi-ye,GUAN Zhi-wei,YU Sheng-yuan,MA Lin. Comparison of 3D Pseudo-continuous Arterial Spin Labeling and Positron Emission Tomography-computed Tomography in the Brain Disorders [J]. Acta Academiae Medicinae Sinica, 2014, 36(4): 377-384. |
| [15] | TIAN Shu-ping,LI Chun-ping,WU Fang,LI Ying-na,SONG Xiang,GAN Lu, CHANG Rui-ping,JU Hai-yue,YANG Li. Value of Coronary Computed Tomography Angiography in Ruling out Coronary Artery Disease Before Intermediate- and High-risk Non-cardiac Surgery [J]. Acta Academiae Medicinae Sinica, 2014, 36(3): 255-260. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
|
