Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (6): 809-816.doi: 10.3881/j.issn.1000-503X.11033
• Original Articles • Previous Articles Next Articles
XU Jia1,WANG Xuan1(),YOU Yan2,XUE Huadan1,WANG Qin1,WANG Shitian1,JIN Zhengyu1
Received:
2018-11-22
Online:
2018-12-20
Published:
2019-01-03
Supported by:
CLC Number:
XU Jia,WANG Xuan,YOU Yan,XUE Huadan,WANG Qin,WANG Shitian,JIN Zhengyu. Gadolinium Ethoxybenzyl Diethylene-triamine-pentaacetic-acid-enhanced Magnetic Resonance Imaging Perfusion and Multiple Hepatobiliary-phase Imaging for Quantitative Assessment of Liver Fibrosis in Rat Models[J].Acta Academiae Medicinae Sinica, 2018, 40(6): 809-816.
Fig 2
HE and Masson staining of liver tissues at different liver fibrosis stages F0:normal liver parenchyma,without liver fibrosis (×400);F1:enlargement of portal tract with rare septa formation (×200);F3:fibrous septa bridging portal triads and central veins(×200);F4:early cirrhosis,nodules of liver parenchyma separated by thick fibrous bands(×40)"
Table 1
Comparisons of perfusion parameters in different liver fibrosis groups(x?±s)"
肝纤维化Fibrosis | Ktrans (min-1) | Kep(min-1) | Ve(min-1) | iAUC | Tmax (s) | REmax (%) |
---|---|---|---|---|---|---|
正常Normal(n=10) | 0.727±0.162 | 1.760±0.316 | 0.449±0.093 | 15.356±3.704 | 150±33 | 97.32±13.86 |
轻度纤维化Mild fibrosis(n=10) | 0.556±0.150 | 1.810±0.294 | 0.346±0.064a | 14.498±3.671 | 138±9 | 92.83±19.87 |
重度纤维化Advanced fibrosis(n=11) | 0.448±0.155b | 1.510±0.355 | 0.332±0.081c | 11.098±5.239 | 189±58de | 82.57±19.51 |
F | 7.011 | 1.916 | 4.656 | 2.253 | 6.633 | 1.903 |
P | 0.005 | 0.193 | 0.023 | 0.100 | 0.005 | 0.169 |
Table 2
Comparisons of multiple hepatobiliary phase parameters in different liver fibrosis groups(x?±s)"
肝纤维化Fibrosis | RE3 min (%) | RE20 min(%) | RE45 min (%) | RE50 min (%) | RE55 min (%) | RE60 min (%) | RE下降(%) | TRE1/2 (s) |
---|---|---|---|---|---|---|---|---|
正常 Normal(n=10) | 83.39±13.86 | 32.22±18.11 | 14.57±7.94 | 7.07±10.61 | 6.08±5.99 | 4.01±4.67 | 91.49±11.39 | 722±156 |
轻度纤维化 Mild fibrosis(n=10) | 80.41±18.35 | 30.25±18.86 | 10.44±6.64 | 7.22±5.46 | 5.51±6.04 | 4.78±4.06 | 89.76±20.20 | 718±110 |
重度纤维化 Advanced fibrosis(n=11) | 77.75±28.98 | 45.94±23.76 | 24.51±14.48e | 24.06±15.48f | 23.78±15.35ag | 19.87±16.71b | 68.58±22.50ch | 1314±778di |
F | 0.080 | 2.343 | 3.994 | 5.276 | 5.189 | 2.689 | 5.343 | 5.493 |
P | 0.923 | 0.115 | 0.030 | 0.020 | 0.002 | 0.039 | 0.014 | 0.010 |
[1] |
Schuppan D, Afdhal NH . Liver cirrhosis[J]. Lancet, 2008,371(9615):838-851. DOI: 10.1016/S0140-6736(08)60383-9.
doi: 10.1016/S0140-6736(08)60383-9 |
[2] |
Poynard T . Impact of interferon Alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C[J]. Hepatology, 2000,32(5):1131-1137. DOI: 10.1053/jhep.2000.19347.
doi: 10.1053/jhep.2000.19347 pmid: 8390560 |
[3] |
Malekzadeh R, Mohamadnejad M, Rakhshani N , et al. Reversibility of cirrhosis in chronic hepatitis B[J]. Clin Gastroenterol Hepatol, 2004,2(4):344-347.
doi: 10.1016/S1542-3565(04)00066-7 pmid: 15067631 |
[4] |
Baranova A, Lal P, Birerdinc A , et al. Non-invasive markers for hepatic fibrosis[J]. BMC Gastroenterol, 2011,11:91. DOI: 10.1186/1471-230X-11-91.
doi: 10.1186/1471-230X-11-91 |
[5] |
Sharma S, Khalili K, Nguyen GC . Non-invasive diagnosis of advanced fibrosis and cirrhosis[J]. World J Gastroenterol, 2014,20(45):16820-16830. DOI: 10.3748/wjg.v20.i45.16820.
doi: 10.3748/wjg.v20.i45.16820 pmid: 25492996 |
[6] |
肖年军, 张爱群, 孟翔飞 , 等. 肝纤维化评估方法的进展[J]. 中华肝脏病杂志, 2014,22(10):792-794. DOI: 10.3760/cma.j.issn.1007-3418.2014.10.017.
doi: 10.3760/cma.j.issn.1007-3418.2014.10.017 |
[7] |
Van Beers BE, Pastor CM, Hussain HK . Primovist,Eovist:what to expect[J]. J Hepatol, 2012,57(2):421-429. DOI: 10.1016/j.jhep.2012.01.031.
doi: 10.1016/j.jhep.2012.01.031 pmid: 22504332 |
[8] |
Chen BB, Hsu CY, Yu CW , et al. Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients[J]. Eur Radiol, 2012,22(1):171-180. DOI: 10.1007/s00330-011-2249-5.
doi: 10.1007/s00330-011-2249-5 pmid: 21879400 |
[9] |
Verloh N, Haimerl M, Zeman F , et al. Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla[J]. Eur Radiol, 2014,24(5):1013-1019. DOI: 10.1007/s00330-014-3108-y.
doi: 10.1007/s00330-014-3108-y pmid: 24531844 |
[10] |
Jang YJ, Cho SH, Bae JH , et al. Noninvasive assessment of hepatic fibrosis using gadoxetate-disodium-enhanced 3T MRI[J]. Ann Hepatol, 2013,12(6):926-934.
pmid: 24114823 |
[11] |
Bastati N, Feier D, Wibmer A , et al. Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease:a proof-of-concept study[J]. Radiology, 2014,271(3):739-747. DOI: 10.1148/radiol.14131890.
doi: 10.1148/radiol.14131890 pmid: 24576046 |
[12] |
Norén B, Forsgren MF, Dahlqvist Leinhard O , et al. Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA[J]. Eur Radiol, 2013,23(1):174-181. DOI: 10.1007/s00330-012-2583-2.
doi: 10.1007/s00330-012-2583-2 pmid: 22836161 |
[13] |
Watanabe H, Kanematsu M, Goshima S , et al. Staging hepatic fibrosis:comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging-preliminary observations[J]. Radiology, 2011,259(1):142-150. DOI: 10.1148/radiol.10100621.
doi: 10.1148/radiol.10100621 pmid: 21248234 |
[14] |
Zhou ZP, Long LL, Qiu WJ , et al. Comparison of 10- and 20-min hepatobiliary phase images on Gd-EOB-DTPA-enhanced MRI T1 mapping for liver function assessment in clinic[J]. Abdom Radiol (NY), 2017,42(9):2272-2278. DOI: 10.1007/s00261-017-1143-2.
doi: 10.1007/s00261-017-1143-2 pmid: 28396918 |
[15] |
Verloh N, Utpatel K, Haimerl M , et al. Detecting liver fibrosis with Gd-EOB-DTPA-enhanced MRI:a confirmatory study[J]. Sci Rep, 2018,8(1):6207. DOI: 10.1038/s41598-018-24316-z.
doi: 10.1038/s41598-018-24316-z |
[16] |
Zhang W, Kong X, Wang ZJ , et al. Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis induced by carbon tetrachloride in rats[J]. PLoS One, 2015,10(6):e0129621. DOI: 10.1371/journal.pone.0129621.
doi: 10.1371/journal.pone.0129621 pmid: 26076199 |
[17] | Ji Y, Zhang C, Huang Z , et al. Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis[J]. Am J Transl Res, 2018,10(9):2949-2957. |
[18] |
Tsuda N, Okada M, Murakami T . New proposal for the staging of nonalcoholic steatohepatitis:evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI[J]. Eur J Radiol, 2010,73(1):137-142. DOI: 10.1016/j.ejrad.2008.09.036.
doi: 10.1016/j.ejrad.2008.09.036 pmid: 19026502 |
[19] |
Haimerl M, Verloh N, Zeman F , et al. Assessment of clinical signs of liver cirrhosis using T1 mapping on Gd-EOB-DTPA-enhanced 3T MRI[J]. PLoS One, 2013,8(12):e85658. DOI: 10.1371/journal.pone.0085658.
doi: 10.1371/journal.pone.0085658 pmid: 3877368 |
[20] |
Sheng RF, Wang HQ, Yang L , et al. Assessment of liver fibrosis using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance[J]. Dig Liver Dis, 2017,49(7):789-795. DOI: 10.1016/j.dld.2017.02.006.
doi: 10.1016/j.dld.2017.02.006 pmid: 28237298 |
[1] | CAI Ning,FU Qiang,ZHANG Yanyang,YU Xinguang. Effect of Flurbiprofen Axetil on Low-frequency Fluctuation Amplitude of Resting-state Functional Magnetic Resonance Imaging in Trigeminal Neuralgia [J]. Acta Academiae Medicinae Sinica, 2019, 41(2): 228-233. |
[2] | LIU Mengqi,LIU You,CHEN Zhiye. Ependymoma in Sellar Region:Report of One Case [J]. Acta Academiae Medicinae Sinica, 2019, 41(1): 139-142. |
[3] | MA Hongli,Lü Furong,XIAO Zhibo,DU Jinchao,SHENG Bo. Comparison of Prenatal Diagnostic Value between Fast Imaging Employing Steady State Acquisition and Single Shot Fast Spin Echo Sequence in Diagnosis of Placental Invasion [J]. Acta Academiae Medicinae Sinica, 2019, 41(1): 86-92. |
[4] | WANG Botao,LIU You,WANG Kun,XU Huan,CHEN Zhiye. Magnetic Resonance Imaging Features of the Supratentorial Extra-axial Hemangioblastoma:A Case Report [J]. Acta Academiae Medicinae Sinica, 2018, 40(6): 847-849. |
[5] | XIE Xiaohong,LIU Mengqi,LI Baige,CHEN Zhiye. Spinal Schwannoma with Entering-and-exiting-nerve Sign:Report of One Case [J]. Acta Academiae Medicinae Sinica, 2018, 40(6): 850-852. |
[6] | XU Aqiao,ZHAO Zhenhua,YANG Jianfeng,WEI Mingzhu,ZHENG Jing,LU Junmin,HU Hongjie,ZHANG Shengjian. Evaluation of Uterine Tumor Angiogenesis with Quantitative Magnetic Resonance Imaging Perfusion Parameters [J]. Acta Academiae Medicinae Sinica, 2018, 40(5): 705-709. |
[7] | LI Lihui,HUANG Houbin,CHEN Zhiye. Contrast Enhanced T2 Fluid-attenuated Inversion Recovery Imaging in Diagnosing Macular Edema Caused by Retinal Vein Occlusion:Report of One Case [J]. Acta Academiae Medicinae Sinica, 2018, 40(5): 719-722. |
[8] | CUI Bao, SUN Xingwang, ZHU Yufen, DU Yuping, CUI Jinguo, MA Lu, CAI Jianming. Relationship between Angiotensin Converting Enzyme Gene Polymorphism and Carotid Atherosclerotic Plaque: A Study Based on Vessel Wall Magnetic Resonance Imaging [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 493-500. |
[9] | YANG Shuai, WANG Xiaoyi, LIAO Weihua, XIAO Haiqing, ZHOU Gaofeng, HU Ping, PENG Xianjing. Magnetic Resonance Imaging Features and Their Pathological Mechanisms of Hashimoto’s Encephalopathy [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 501-509. |
[10] | WU Peng, ZHANG Yujiao, QIN Fang, LIU Lan, CUI Shujun. Diffusion Tensor Imaging in Early Diagnosis and Prognostic Prediction of Intervertebral Disc Change in Patients with Brucella Spondylitis [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 519-527. |
[11] | ZHOU Ping, YAN Chaoqun, ZHANG Shuai, HUO Jianwei, LIU Cunzhi. Research Advances in Insomnia Disorder Based on Magnetic Resonance Imaging [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 543-548. |
[12] | XU Huan, ZHANG Xiaohuan, WANG Kun, FAN Wenping, WANG Xue, YUN Jie, CHEN Zhiye. Diagnostric Value of Contrast-enhanced T2 Fluid-attenuated Inversion Recovery Imaging for Splenic Hemangioma:A Case Report [J]. Acta Academiae Medicinae Sinica, 2018, 40(4): 573-576. |
[13] | XU Huan, WANG Botao, WANG Kun, WANG Xue, FAN Wenping, CHEN Zhiye. Epidermoid Cyst in the Fourth Ventricle:Report of One Case [J]. Acta Academiae Medicinae Sinica, 2018, 40(3): 436-438. |
[14] | WANG Botao, HE Lei, LIU Gang, LIU Mengqi, CHEN Zhiye. Value of Magnetic Resonance Imaging Texture Feature Analysis in the Differential Diagnosis between Pancreatic Serous Cystadenoma and Mucinous Cystadenoma [J]. Acta Academiae Medicinae Sinica, 2018, 40(2): 187-193. |
[15] | XING Xinbo, XI Wei, WANG Xinkun, YANG Shuhui, NIE Mingming, HU Mingyan, REN Jingmei, YANG Jiafei, LOU Xin. Value of Magnetic Resonance Imaging Findings in Differential Diagnosis between the Adult Reversible Splenial Lesion Syndrome and Ischemic Infarction of the Splenium of the Corpus Callosum [J]. Acta Academiae Medicinae Sinica, 2018, 40(2): 233-241. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||
|