Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (5): 714-718.doi: 10.3881/j.issn.1000-503X.11197

• Case Reports • Previous Articles     Next Articles

Leucine-rich Glioma-inactivated Protein 1 Antibody-associated Encephalitis:Report of Two Cases

ZHAO Junjie(),YANG Yanhong   

  1. Department of Neurology,Jinan People’s Hospital of Shandong Province,Jinan 271100,China
  • Received:2019-01-25 Online:2019-10-30 Published:2019-11-08
  • Contact: Junjie ZHAO


Leucine-rich glioma-inactivated protein 1(LGI1)antibody-associated encephalitis is an autoimmune brain disease mainly seen in mid-aged and elderly people.Its main clinical manifestations include abnormal mental behaviors,facial-arm dystonia,hyponatremia,and hypokalemia.Immunotherapy with gamma globulin and/or hormone is effective.Two patients with LGT1 antibody-associated encephalitis were diagnosed in our center between January 2018 and October 2018,with typical clinical findings.The disease was cursed after immunoglobulin and hormone treatments.

Key words: leucine-rich glioma inactivation 1 protein, limbic encephalitis, magnetic resonance imaging, facial-arm dystonia

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