Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (5): 685-689.doi: 10.3881/j.issn.1000-503X.11698

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Coagulation Disorders in Bullous Pemphigoid and Its Mechanism

YAN Tianmeng1,ZUO Yagang2()   

  1. 1 Department of Dermatology,The University of Hong Kong-Shenzhen Hospital,Shenzhen 518053,China
    2 Department of Dermatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2019-06-24 Online:2019-10-30 Published:2019-11-08
  • Contact: Yagang ZUO
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81972944);Beijing Natural Science Foundation(7192166);the High Level-Hospital Program,Health Commission of Guangdong Province,China(HKUSZH201901037)


Bullous pemphigoid(BP)is an autoimmune blister disease caused by antibodies to the basement membrane zone.It usually exhibits tense bullae in skin and mucous membrane.BP patients can suffer from thrombosis due to hypercoagulation and/or hemorrhage due to the presence of anti-coagulation factors,which may be explained by the eosinophils,antibodies to the coagulation factors,and fibrinolytic system hyperactivity or inhibition.

Key words: bullous pemphigoid, coagulation, anticoagulant system, fibrinolysis

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