Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2008, Vol. 30 ›› Issue (6): 723-727.doi: 10.3881/j.issn.1000-503X.2008.06.019

• Original Articles • Previous Articles     Next Articles

Inductions and Intubating Conditions with Sevoflurane and Different Doses of Remifentanil without Muscle Relaxant in Children

WEI Ling-xin;DENG Xiao-ming;LIU Ju-hui;LUO Mao-ping; TONG Shi-yi; ZHANG Yan-ming; LIAO Xu; XU Kun-lin   

  1. Department of Anesthesiology,Plastic Surgery Hospital,CAMS and PUMC,Beijing 100144, China
  • Received:2008-03-26 Revised:1900-01-01 Online:2008-12-30 Published:2008-12-30
  • Contact: DENG Xiao-ming

Abstract: ABSTRACT:Objective To observe the clinical effectiveness of inductions and tracheal intubating conditions with 3% sevoflurane and different doses of remifentanil without muscle relaxant in children. Methods Totally 120 peadiatric patients (aged 4-10 years, American Society of Anesthesiologists gradeⅠfor inhalational induction) were randomly allocated into groupⅠ(remifentanil 1 μg/kg), group Ⅱ(remifentanil 2 μg/kg), group Ⅲ (remifentanil 3 μg/kg), and control group (vecuronium bromide 0.1 mg/kg). After inhalational induction with 3% sevoflurane and 60% nitrous oxide in 40% oxygen for 2 minutes, remifentanil 1 μg/kg, 2 μg/kg, and 3 μg/kg were intravenously injected over 1 minute into patients in group Ⅰ, group Ⅱ, and group Ⅲ, respectively. After remifentanil administration and manual ventilation for 1 minute, the trachea was intubated. In the control group, 2 minutes after intravenous administration of vecuronium bromide 0.1 mg/kg, tracheal intubation was attempted. Agitation, intubating satisfactoriness, and the circulation changes after tracheal intubation and anesthesia induction were observed. Results In these four groups, agitation occurred in 37.5% of patients during sevoflurane induction. Satisfactory intubation rate was 70.0% in groupⅠ, 86.7% in groupⅡ, 90.0% in group Ⅲ, and 93.3% in the control group. Compared with the control group, the impact of tracheal intubation on the circulatory system was smaller in group Ⅰ,Ⅱ, and Ⅲ. Conclusions Induction with 3% sevoflurane combined with remifentanil can be smoothly performed, followed by the successful tracheal intubation. The intubating conditions are more satisfactory with 3% sevoflurane combined with remifentanil 2 μg/kg or 3 μg/kg.

Key words: sevoflurane, remifentanil, tracdeal intubation