Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2008, Vol. 30 ›› Issue (6): 741-746.doi: 10.3881/j.issn.1000-503X.2008.06.023

• Reviews • Previous Articles     Next Articles

Neuronal Plasticity of Otolith-related Vestibular System

Suk-king Lai1,2, Chun-hong Lai 1, Fu-xing Zhang1,3, Chun-wai Ma1,3, Daisy K.Y. Shum2,3, Ying-shing Chan1,2   

  1. 1Department of Physiology, 2Research Centre of Heart, Brain, Hormone and Healthy Aging, 3Department of Biochemistry, LKS Faculty of Medicine,The University of Hong Kong, Hong Kong, China
  • Received:2008-07-03 Revised:1900-01-01 Online:2008-12-30 Published:2008-12-30
  • Contact: Ying-shing Chan

Abstract: ABSTRACT:This review focuses on our effort in addressing the development and lesion-induced plasticity of the gravity sensing system. After severance of sensory input from one inner ear, there is a bilateral imbalance in response dynamics and spatial coding behavior between neuronal subpopulations on the two sides.These data provide the basis for deranged spatial coding and motor deficits accompanying unilateral labyrinthectomy.Recent studies have also confirmed that both glutamate receptors and neurotrophin receptors within the bilateral vestibular nuclei are implicated in the plasticity during vestibular compensation and development.Changes in plasticity not only provide insight into the formation of a spatial map and recovery of vestibular function but also on the design of drugs for therapeutic strategies applicable to infants or vestibular disorders such as vertigo and dizziness.

Key words: otolitdic orcan, spatial recocnition, clutamate receptor, vestibular system compensation