Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (1): 6-9.doi: 10.3881/j.issn.1000-503X.2009.01.003

• Original Articles • Previous Articles     Next Articles

Effect of Combined Herbal Medicine Therapy on the Expression of Psoriasis-associated Antigen-Pso p27 in Patients with Psoriasis Vulgaris

SONG Ping1,2; Hilde Lysvand3; YAN Yu-he1;LIU Wa-li1;Ole-Jan Iversen3   

  1. 1Department of Dermatology, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    2Department of Neurology, Dong Zhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    3Department of Laboratory Medicine, Childrens and Womens Health, Faculty of Medicine,Norwegian University of Science and Technology, Trondheim 7489, Norway
  • Received:2008-10-31 Revised:1900-01-01 Online:2009-02-28 Published:2009-02-28
  • Contact: LIU Wa-li;Ole-Jan Iversen

Abstract: ABSTRACT:Objective To evaluate the effect of combined herbal medicine therapy on the expression of psoriasis-associated antigen (Pso p27) in patients with psoriasis vulgaris. Methods Fifteen psoriasis vulgaris patients were included in the study and they were all treated with combined herbal medicine therapy for 12 weeks. Both psoriasis area and severity index (PASI) score and plaque index (PI) score were evaluated before and after treatment, while skin biopsies from selected lesions and uninvolved skin near the lesions were performed. Expression of Pso p27 in the target skin and surrounding uninjured skins were analysed using immuno-fluorescence method. Results The PASI score and PI score decreased after the combined herbal medicine therapy in both acute and silent stages(P<0.01), so did the positive cells of Pso p27 and the intensity of fluorescein stain (P<0.05). Conclusion The combined herbal medicine therapy is effective in treating psoriasis vulgaris in both acute and silent stages, which may be resulted from its inhibition of the expression of Pso p27.

Key words: pso p27, psoriasis vulcaris, combined derbal medicine tderapy