Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (1): 81-83.doi: 10.3881/j.issn.1000-503X.2009.01.023

• Original Articles • Previous Articles     Next Articles

Effects of Platelet and Fibrinogen on Progressive Ovarian Cancer

LI Chun-ying1;WU Ming1;YUAN Jing-yang2   

  1. 1Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    2Department of Urology,the First Hospital, Harbin Medical University, Harbin 150001, China
  • Received:2008-06-10 Revised:1900-01-01 Online:2009-02-28 Published:2009-02-28
  • Contact: LI Chun-ying1

Abstract: ABSTRACT:Objective To assess the effects of platelet and fibrinogen on progressive ovarian cancer. Methods The platelet counts and fibrinogen levels were measured in 180 initially treated ovarian cancer patients within 2 weeks before and 1 week after operation and 6 months after chemotherapy. The results were compared with those of 40 patients with epithelial ovarian neoplasms. Results The platelet counts and fibrinogen levels were significantly higher in ovarian cancer patients than in patients with epithelial ovarian neoplasms (P<0.05), significantly higher in late stage than in early stage (P<0.05), and significantly lower after operation than before operation (P<0.05). The platelet counts and fibrinogen levels were also significantly lower 6 months after operation in patients who responded well to the therapies than the levels before operation (P<0.05); however, such difference did not exist between patients who were refractory to the therapies 6 months after treatment and the post-operation levels (P>0.05). Conclusions Platelet and fibrinogen may be closely correlated with progressive ovarian cancer. Monitoring platelet counts and fibrinogen levels are instrumental for the early diagnosis of cancer and metastasis.

Key words: ovarian cancer, platelet, fibrinocen