Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (2): 206-209.doi: 10.3881/j.issn.1000-503X.2009.02.017

• Original Articles • Previous Articles     Next Articles

Application of 1H-magnetic Resonance Spectroscopy in Differential Diagnosis of Brain Low-grade Gliomas and Demyelinating Diseases

HOU Xin-yi; GAO Pei-yi   

  1. Imaging Center of Neuroscience, Beijing Neurosurgical Institute, Beijing Tiantan Hospital,Capital Medical University, Beijing 100050, China
  • Received:2008-12-19 Revised:1900-01-01 Online:2009-04-30 Published:2009-04-30
  • Contact: GAO Pei-yi

Abstract: ABSTRACT:Objective To study the clinical value of 1H-magnetic resonance spectroscopy (1H-MRS) in differential diagnosis of brain low-grade gliomas and demyelinating diseases. Methods 1H-MRS was performed in 24 patients with low-grade gliomas and 22 patients with demyelinating diseases and the Results were retrospectively reviewed. The metabolites including N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) were detected in different areas including lesions and the normal brain. The ratios of NAA /Cr, NAA/Cho, and Cho/Cr were also computed. Results Compared with the normal brain tissue, low-grade gliomas and demyelinating diseases had significantly different ratios of NAA/Cr, NAA/Cho, and Cho/Cr (P<0.05). The ratios of NAA/Cho and Cho/Cr were significantly different between low-grade gliomas and demyelinating diseases (P<0.05), while the ratio of NAA/Cr was not significantly different (P>0.05). Conclusions The ratio of NAA/Cho and Cho/Cr is remarkably different between low-grade gliomas and demyelinating diseases. It can a useful indicator for differential diagnosis of these two diseases by 1H-MRS.

Key words: low-crade clioma, demyelinatinc disease, 1d-macnetic resonance spectroscopy