Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (3): 292-295.doi: 10.3881/j.issn.1000-503X.2009.03.010

• Postoperative management Forum of Hepatic transplantation • Previous Articles     Next Articles

Pathogenesis of Post-transplantation Diabetes Mellitus in 40 Renal Transplantation Recipients

WANG Zhen;SHI Bing-yi;ZHENG Hui-li;QIAN Ye-yong;HAN Meng-xia   

  1. Organ Transplantation Center, the Second Affiliated Hospital of PLA General Hospital, Beijing 100091,China
  • Received:2009-02-25 Revised:1900-01-01 Online:2009-06-30 Published:2009-06-30
  • Contact: SHI Bing-yi

Abstract: ABSTRACT:Objective To explore pathogenesis of post-transplantation diabetes mellitus(PTDM) in renal transplantation recipients. Methods A total of 40 renal transplantation recipients were divided into three groups based on oral glucose tolerance test results: normal glucose tolerance(NGT) group(n=10), impaired fasting glycaemia+impaired glucose tolerance (IFG+IGT) group (n=16), and PTDM group (n=14).Insulin resistance (IR) and β cell function were assessed by homeostasis model. Results The differences of the immunosuppressive agents used in these groups were not statistically significant(P>0.05). Compared with NGT group, insulin area under curve and homeostasis model assessment-insulin resistance index were significantly higher in IGT+ IFG group and PTDM group(P<0.05). Compared with NGT group and IGT+IPG group, insulin secretion index at 30 min and homeostasis model assessment-insulin secretion index were significantly lower in PTDM group(P<0.05). Conclusion Insulin resistance and β-cell dysfunction may play a key role in the pathogenesis of PTDM.

Key words: post-transplantation diabetes mellitus, insulin resistance, islet β-cell function, patdocenesis