Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (4): 494-497.doi: 10.3881/j.issn.1000-503X.2009.04.022

• Original Articles • Previous Articles     Next Articles

Changes of Insulin Resistance and Islet β Cells Function in Subjects with High-normal Blood Pressure

XU Ling-ling;XIANG Hong-ding;ZHANG Li-hong; CHEN Wei; FANG Jing-hui   

  1. Department of Endocrinology, Key Laboratory of Endocr inology Ministry of Health,
    PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2009-02-17 Revised:1900-01-01 Online:2009-08-30 Published:2009-08-30
  • Contact: XIANG Hong-ding

Abstract: ABSTRACT:Objective To investigate the changes of insulin resistance and islet β cells function in subjects with euglycemia and high-normal blood pressure. Methods Total 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and 1PH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group(P<0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r=0.122) and negatively correlated with 1PH Stumvoll index (r=-0.159) and ISI-composite (r=-0.131) (P<0.05). SBP and triglyceride were independent factors for 1PH Stumvoll index. Conclusion Insulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.

Key words: insulin resistance, β cell function, blood pressure