Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (4): 506-510.doi: 10.3881/j.issn.1000-503X.2009.04.025

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Advances in Clinical Applications of T-SPOT.TB for Interferon-gamma Release Assay in the Immunodiagnosis of Tuberculosis

ZHANG Li-fan;LIU Xiao-qing   

  1. Department of Infectious Diseases, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2009-05-19 Revised:1900-01-01 Online:2009-08-30 Published:2009-08-30
  • Contact: LIU Xiao-qing

Abstract: ABSTRACT:T-SPOT.TB is an interferon-gamma release assay to detect T-cell response to early secreting antigen target 6 and culture filtrate protein 10 peptides by enzyme-linked immunospot assay for tuberculosis diagnosis. It is highly sensitive and specific, and will not be affected by the subject’s immune status and Bacillus Calmette-Guerin vaccination. This assay has been licensed for in-vitro diagnosis in Europe and the United States. Its potential roles in distinguishing active tuberculosis from latent tuberculosis infection and predicting active tuberculosis among individuals with latent tuberculosis have been increasingly studies. This article reviews the advances in the clinical application of T-SPOT.TB.

Key words: tuberculosis immunolocy, tuberculosis diacnosis, active tuberculosis, latent tuberculosis, t-spot.tb, interferon-camma release assay