Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (4): 511-515.doi: 10.3881/j.issn.1000-503X.2009.04.026

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Potential Value of Mycobacterium Tuberculosis RD1 Region-encoded Proteins in the Diagnosis of Tuberculosis

DU Feng-jiao;CHEN Xi;LIU Fei;ZHANG Zong-de


  1. Laboratory of Molecular Biology for Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China
  • Received:2009-04-01 Revised:1900-01-01 Online:2009-08-30 Published:2009-08-30
  • Contact: ZHANG Zong-de

Abstract: ABSTRACT:Nine proteins encoded by Mycobacterium tuberculosis RD1 region are important protective antigens that become absent in long passaging of Mycobacterium tuberculosis. They only exist in pathogenic Mycobacteria and are absent in Bacille Calmette-Guerin and environmental Mycobacteria. With good immunogenicities, they may play an important role in the diagnosis and prevention of Mycobacterium tuberculosis. This article reviews recent studies on using RD1-encoded proteins as antigens in the diagnosis of active tuberculosis and tuberculous pleurisy.

Key words: rd1 recion, mycobacterium tuberculosis, active tuberculosis, tuberculous pleurisy