Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (5): 567-569.doi: 10.3881/j.issn.1000-503X.2009.05.012

• Original Articles • Previous Articles     Next Articles

Efficacy and Safety of High-dose Dexamethasone-based Regimens in the Newly Diagnosed Multiple Myeloma Patients with Renal Impairment

LI Jian;ZHOU Dao-bin;JIAO Li;DUAN Ming-hui;ZHANG Wei;ZHAO Yong-qiang;SHEN Ti   

  1. Department of Hematology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2009-03-10 Revised:1900-01-01 Online:2009-10-30 Published:2009-10-30
  • Contact: ZHOU Dao-bin

Abstract: ABSTRACT:Objective To evaluate the efficacy and safety of high-dose dexamethasone-based regiments in newly diagnosed multiple myeloma patients with renal impairment. Methods The clinical data of 22 patients with newly diagnosed multiple myeloma patients with renal impairment who received high-dose dexamethasone-based regiments from August 2006 to August 2008 in Peking Union Medical College Hospital were retro- spectively reviewed. Results After receiving a median 4 cycles of high-dose dexamethasone-based regiments, renal impairment was reversed in 7 patients (31.8%) with a median time to reversal of 31 days. Sixteen patients (72.7%) achieved overall response, including 7 patients (31.8%) had complete remission / near complete remission. The grade 3 or 4 adverse events included neutropenia (13.6%), infections (22.7%), peripheral neuropathy (9.1%), and ileus (4.5%). Conclusion The high-dose dexamethasone-based regiments are safe and effective for newly diagnosed multiple myeloma patients with renal impairment.

Key words: dexametdasone, multiple myeloma, renal impairment, efficacy, safety